Assessment of tissue fibrosis in skin biopsies from patients with systemic sclerosis employing confocal laser scanning microscopy: an objective outcome measure for clinical trials? [PDF]
OBJECTIVES: To obtain an objective, unbiased assessment of skin fibrosis in patients with SSc for use in clinical trials of SSc disease-modifying therapeutics.
Busquets, Joanna+3 more
core +3 more sources
Scleroderma with Nodular Scleroderma
Background: Nodular scleroderma is a rare variant of scleroderma which can occur in connection with systemic sclerosis or morphea. A biopsy from the lesion can demonstrate the scleroderma pattern, i.e., keloid pattern or mixed type.
Chutika Srisuttiyakorn+1 more
doaj +1 more source
Cerebral infarction caused by systemic sclerosis: a case report
Systemic sclerosis, also known as scleroderma, is a rare multisystem autoimmune disease characterized by vascular lesions caused by collagen deposition in the skin and viscera and damage to the endothelium.
Qingqing Wang+3 more
doaj +1 more source
Calcinosis circumscripta of the breasts: The deeper meaning
Calcinosis circumscripta involving the breasts usually hints at an underlying systemic cause, most commonly connective tissue disorders such as scleroderma or dermatomyositis.
Tanusha Sewchuran, Joel M. Kabeya
doaj +1 more source
A prospective observational study of mycophenolate mofetil treatment in progressive diffuse cutaneous systemic sclerosis of recent onset. [PDF]
OBJECTIVE: A prospective observational study of mycophenolate mofetil (MMF) treatment in patients with diffuse progressive cutaneous systemic sclerosis (SSc) of recent onset.
Jimenez, Sergio A.+3 more
core +3 more sources
Improvement of mouth functional disability in systemic sclerosis patients over one year in a trial of fat transplantation versus adipose-derived stromal cells [PDF]
Background. Systemic sclerosis (SSc) is a multisystem disease characterized by cutaneous and visceral fibrosis. Face and mouth changes include telangiectasia, sicca syndrome, and thinning and reduction of mouth width (microcheilia) and opening ...
CARELLA, SARA+5 more
core +4 more sources
Systemic Sclerosis Manifesting Post-Radiotherapy: A Case Report
Morphoea is a chronic inflammatory disease of the skin and underlying tissues, characterised by fibrosis of the skin and subcutaneous tissue without systemic involvement.
Devanshi Nimbark+2 more
doaj +1 more source
Systemic sclerosis (SSc) is a heterogeneous connective tissue disease that is typically subdivided into limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) depending on the extent of skin involvement.
V. Sobanski+259 more
semanticscholar +1 more source
Cerebral Sinus Thrombosis in Scleroderma: A Case Report [PDF]
Scleroderma or systemic sclerosis is a multisystem disease due to excessive collagen deposition in different organs and autoimmunity by production of autoantibodies.According to previous reports, brain is rarely affected in scleroderma, howeverrecent ...
Maryam Poursadegh Fard+1 more
doaj +2 more sources
THE SYSTEMIC INVOLVEMENT IN SCLERODERMA [PDF]
A survey was made of the systemic involvement in 38 patients with scleroderma: 33 with the acrosclerotic form (Type 1, 18, Type 2, 15) and five with the diffuse form. The study comprised inquiry about symptoms, physical examination, and the laboratory tests, such as radiological examination of chest and hands, barium swallow and meal X-ray examination,
openaire +2 more sources