Results 11 to 20 of about 80,483 (293)

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. [PDF]

, 2015
In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of ...
Abraham, D, Ahmed-Abdi, B, Denton, C, Lafyatis, R, Layne, MD, Nikitorowicz-Buniak, J, Ponticos, M, Shiwen, X, Smith, BD, Stratton, R, Suki, B, Takahashi, A   +11 more
core   +28 more sources

Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma. [PDF]

, 2020
ObjectiveAutoimmune responses to DNA topoisomerase I (topo I) are found in a subset of scleroderma patients who are at high risk for interstitial lung disease (ILD) and mortality.
Boin, Francesco, Cole, Robert N, Darrah, Erika, Fava, Andrea, Guhr, Tara, McMahan, Zsuzsanna H, O'Meally, Robert N, Shah, Ami A, Tiniakou, Eleni, Wigley, Fredrick M   +9 more
core   +1 more source

Early nurturing experiences, self-compassion, hyperarousal and scleroderma the way we relate to ourselves may determine disease progression [PDF]

, 2016
<p>Scleroderma is a rare, painful and complex autoimmune connective tissue disease that can lead to death. The physiology of symptom onset and progression and the psychological aspects of living with this chronic disease have been studied fairly ...
Hicks, Richard E., Kearney, Karen
core   +1 more source

Clinical and serological features of systemic sclerosis in a multicenter African American cohort: Analysis of the genome research in African American scleroderma patients clinical database. [PDF]

, 2017
Racial differences exist in the severity of systemic sclerosis (SSc). To enhance our knowledge about SSc in African Americans, we established a comprehensive clinical database from the largest multicenter cohort of African American SSc patients assembled
Boin, Francesco, Carns, Mary, Chung, Lorinda, Criswell, Lindsey A, Derk, Chris T, Domsic, Robyn T, Gladue, Heather, Goldberg, Avram, Gordon, Jessica K, Gourh, Pravitt, Hsu, Vivien, Jan, Reem, Kastner, Daniel L, Khanna, Dinesh, Mayes, Maureen D, Medsger, Thomas A, Morgan, Nadia D, Ramos, Paula S, Remmers, Elaine F, Saketkoo, Lesley A, Schiopu, Elena, Shah, Ami A, Shanmugam, Victoria K, Silver, Richard M, Steen, Virginia D, Trojanowski, Marcin A, Valenzuela, Antonia, Varga, John, Wigley, Fredrick M   +28 more
core   +1 more source

Pharmacological Inhibition of Toll-Like Receptor-4 Signaling by TAK242 Prevents and Induces Regression of Experimental Organ Fibrosis

Frontiers in Immunology, 2018
Systemic sclerosis (SSc) is a poorly understood heterogeneous condition with progressive multi-organ fibrosis. Recent genetic and genomic evidence suggest a pathogenic role for dysregulated innate immunity and toll-like receptor (TLR) activity in SSc ...
Swati Bhattacharyya, Wenxia Wang, Zenshiro Tamaki, Bo Shi, Anjana Yeldandi, Yasuhiro Tsukimi, Masashi Yamasaki, John Varga   +7 more
doaj   +1 more source

Collaboration between patient organisations and a clinical research sponsor in a rare disease condition: learnings from a community advisory board and best practice for future collaborations

BMJ Open, 2020
Introduction Transparent collaborations between patient organisations (POs) and clinical research sponsors (CRS) can identify and address the unmet needs of patients and caregivers.
Ilaria Galetti, Maureen Sauve, Catarina Leite, Joep Welling, Martina Gahlemann, Annelise Roennow, Robert J Riggs, Ann Tyrrell Kennedy, Edith Brown, Alex Gonzalez, Alexandra Paula Portales Guiraud, François Houÿez, Rob Camp, Annie Gilbert, Lizette Moros, Jose Luis Luna Flores, Friedrich Schmidt, Wiebke Sauter, Henrik Finnern   +18 more
doaj   +1 more source

Oxidative stress in the pathogenesis of systemic scleroderma: An overview [PDF]

, 2018
Systemic sclerosis (SSc) is a rare disorder of the connective tissue characterized by fibrosis of the skin, skeletal muscles and visceral organs. Additional manifestations include activation of the immune system and vascular injury. SSc causes disability
Gambardella, Lucrezia, Giovannetti, Antonello, Malorni, Walter, Pietraforte, Donatella, Straface, Elisabetta, Vona, Rosa   +5 more
core   +1 more source

Advanced Autoantibody Testing in Systemic Sclerosis

Diagnostics, 2023
Systemic sclerosis is a systemic autoimmune rheumatic disease characterized by immune abnormalities, leading to vasculopathy and fibrosis. Autoantibody testing has become an increasingly important part of diagnosis and prognostication.
Kholoud Almaabdi, Zareen Ahmad, Sindhu R. Johnson   +2 more
doaj   +1 more source

Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis

Arthritis Research & Therapy, 2018
Background A pivotal role for adipose tissue homeostasis in systemic sclerosis (SSc) skin fibrosis is increasingly recognized. The nuclear receptor PPAR-γ is the master regulator of adipogenesis.
Benjamin Korman, Roberta Goncalves Marangoni, Gabriel Lord, Jerrold Olefsky, Warren Tourtellotte, John Varga   +5 more
doaj   +1 more source

Fibrosing arthropathy in juvenile scleroderma

Современная ревматология, 2021
The group of scleroderma diseases includes a number of clinical entities, the main symptom of which is skin tightening. Scleroderma is a prominent example of these diseases, characterized by excessive synthesis and deposition of collagen in organs and ...
D. A. Dibrov, M. N. Starovoitova, O. V. Desinova   +2 more
doaj   +1 more source