Lung ultrasound in systemic sclerosis: correlation with high-resolution computed tomography, pulmonary function tests and clinical variables of disease [PDF]
, 2015 Interstitial lung disease (ILD) is a hallmark of systemic sclerosis (SSc). Although high-resolution computed tomography (HRCT) is the gold standard to diagnose ILD, recently lung ultrasound (LUS) has emerged in SSc patients as a new promising technique ...
Amoroso, Antonio +8 more
core +1 more source
Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis
Arthritis Research & Therapy, 2018 Background A pivotal role for adipose tissue homeostasis in systemic sclerosis (SSc) skin fibrosis is increasingly recognized. The nuclear receptor PPAR-γ is the master regulator of adipogenesis.
Benjamin Korman +5 more
doaj +1 more source
Clinical and serological features of systemic sclerosis in a multicenter African American cohort: Analysis of the genome research in African American scleroderma patients clinical database. [PDF]
, 2017 Racial differences exist in the severity of systemic sclerosis (SSc). To enhance our knowledge about SSc in African Americans, we established a comprehensive clinical database from the largest multicenter cohort of African American SSc patients assembled
Boin, Francesco +28 more
core +1 more source
Systemic sclerosis sine scleroderma.
Advances in Clinical and Experimental Medicine, 2017 Systemic sclerosis is a rare generalized disease with scleroderma, i.e. skin thickening as one of the most common symptoms. The disease has 2 main subsets, diffuse and limited forms.
E. Kucharz, M. Kopeć-Mędrek
semanticscholar +1 more source
Consensus-based recommendations for the management of juvenile localised scleroderma
Annals of the Rheumatic Diseases, 2019 In 2012, a European initiative called Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic and management regimens in Europe for children and young adults with rheumatic diseases ...
F. Zulian +18 more
semanticscholar +1 more source
Exploring Sources of Emotional Distress among People Living with Scleroderma: A Focus Group Study. [PDF]
PLoS ONE, 2016 BACKGROUND:Systemic sclerosis, or scleroderma, is a chronic and rare connective tissue disease with negative physical and psychological implications. Sources of emotional distress and the impact they have on the lives of people with scleroderma are not ...
Stephanie T Gumuchian +13 more
doaj +1 more source
Fibrosing arthropathy in juvenile scleroderma
Современная ревматология, 2021 The group of scleroderma diseases includes a number of clinical entities, the main symptom of which is skin tightening. Scleroderma is a prominent example of these diseases, characterized by excessive synthesis and deposition of collagen in organs and ...
D. A. Dibrov +2 more
doaj +1 more source
Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta. [PDF]
, 1994 A hallmark of systemic sclerosis (SSc) is the development of tissue fibrosis. Excessive production of several connective tissue components normally present in the dermis, including type I, III, V, and VI collagens as well as fibronectin and proteoglycans,
Christiano, Angela M. +5 more
core +3 more sources
Mortality and morbidity in scleroderma renal crisis: A systematic literature review
Journal of Scleroderma and Related Disorders, 2020 Objectives: The objective of this study was to systematically review the mortality and morbidity associated with scleroderma renal crisis and to determine temporal trends.
Hyein Kim +3 more
semanticscholar +1 more source
Arthritis Research & Therapy, 2017 Background Prokinetics are used to treat enteric dismotility symptoms in systemic sclerosis (SSc) patients, but they often lack adequate efficacy. The most effective prokinetics belonging to the serotonin (5-HT4) receptor agonists class were withdrawn ...
Barbara Vigone +8 more
doaj +1 more source