Results 61 to 70 of about 2,859 (161)

Autoimmune Diseases: Molecular Pathogenesis and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
This review provides a comprehensive overview of common autoimmune diseases, details clinical manifestations and summarizes the pathogenesis, including the breakdown of immune tolerance, initiation of autoimmune responses, and their progressive amplification.
Xiaoshuang Song, Hantian Liang, Fang Nan, Wenjing Chen, Junyao Li, Liu He, Yiping Cun, Zhenhong Li, Wei Zhang, Dunfang Zhang   +9 more
wiley   +1 more source

Profile of systemic sclerosis and associated renal involvement

Archives of Medicine and Health Sciences, 2015
Background: Systemic sclerosis (SSc) patients are encountered in all parts of the world. Few Indian studies are found in the literature on this connective tissue disorder of unknown etiology.
Neehar Shanavas, Anup K Das
doaj   +1 more source

An Integrative Mechanistic Model of Type 1 IFN‐Mediated Inflammation in Systemic Lupus Erythematosus

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 7, Page 1225-1235, July 2025.
ABSTRACT Type I interferon (IFN1) pathway–targeting therapies represent a highly promising class of remedies for the treatment of systemic lupus erythematosus. However, the overall clinical benefit of these compounds is afflicted by marked variability.
Alina Volkova, Victor Sokolov, Florencia Tettamanti, Meghna Verma, Yaroslav Ugolkov, Kirill Peskov, Weifeng Tang, Holly Kimko   +7 more
wiley   +1 more source

Atypical rapid onset Scleroderma Renal Crisis (SRC) complicated with diffuse alveolar hemorrhage and pleuro-pericardial effusions in a patient with recently diagnosed breast cancer and a positive anti-RNA polymerase III Ab.: A case report

Respiratory Medicine Case Reports, 2018
Scleroderma associated Pulmonary–Renal Syndrome is a rare but severe complication with a poor prognosis and high mortality. A high index of suspicion is needed for early recognition of this potential complication in patients with systemic sclerosis and ...
Hazim Bukamur, Obadah Aqtash, Ibrahim Shahoub, Emhemmid Karem, Iheanyichukwu Ogu, Fuad Zeid   +5 more
doaj  

Intersticial pulmonary disease in patients with systemic sclerosis. Narrative review of the literature

Iatreia, 2017
Introduction: Systemic sclerosis is a chronic autoimmune disease, characterized by the triad of small vessel vasculopathy, immune system activation and increased deposits of extracellular matrix in the skin and internal organs.
Álvarez-Barreneche, María Fernanda, Velásquez-Franco, Carlos Jaime, Mesa-Navas, Miguel Antonio   +2 more
doaj   +1 more source

Efficacy and Safety of Rituximab in Connective Tissue Disease‐Associated Thrombotic Thrombocytopenic Purpura/Thrombotic Microangiopathy

International Journal of Rheumatic Diseases, Volume 28, Issue 6, June 2025.
ABSTRACT Introduction This study examined the efficacy and safety of Rituximab (RTX) treatment in connective tissue disease (CTD)‐associated thrombocytopenic purpura (TTP) and thrombotic microangiopathy (TMA), using historical controls as comparators.
Naoaki Ohkubo, Shingo Nakayamada, Shunsuke Fukuyo, Yusuke Miyazaki, Yoshino Inoue, Hiroaki Tanaka, Yasuyuki Todoroki, Yoshiya Tanaka   +7 more
wiley   +1 more source

CURRENT VIEWS ON THE HETEROGENEITY OF RENAL INVOLVEMENTS IN PATIENTS WITH SYSTEMIC SCLEROSIS

Научно-практическая ревматология, 2015
Systemic sclerosis (SS), is an autoimmune connective tissue disease, the main clinical signs of which are due to disseminated microcirculatory disorders and fibrosis of the skin and viscera.
A. V. Gordeev, A. Yu. Zakharova, Z. Yu. Mutovina, L. P. Ananyeva   +3 more
doaj   +1 more source

Renal pathology and clinical associations in systemic sclerosis: a historical cohort study

International Journal of General Medicine, 2019
Pantipa Tonsawan,1 Komkid Talabthong,1 Anucha Puapairoj,2 Chingching Foocharoen11Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 2Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen ...
Tonsawan P, Talabthong K, Puapairoj A, Foocharoen C   +3 more
doaj  

Clinical Images: Interstitial lung disease in Sjögren disease in association with systemic sclerosis

ACR Open Rheumatology, Volume 7, Issue 7, July 2025.
Brandon M. Law, Laura J. Yockey, Eman Seyal, William C. Faquin   +3 more
wiley   +1 more source

Drug-induced scleroderma-like lesion

Allergology International, 2022
Drug-induced scleroderma-like lesion is a condition in which administration of a drug induces skin sclerotic lesions similar to systemic sclerosis or morphea.
Yasuhito Hamaguchi
doaj