Results 131 to 140 of about 25,148 (309)

Sclerostin Blood Levels Before and After Kidney Transplantation

Kidney & Blood Pressure Research, 2014
Background/Aims: Sclerostin is secreted by osteocytes. As a circulating inhibitor of the Wnt-signaling pathway it inhibits bone formation and contributes to the development of osteoporosis.
Marco Bonani, Daniel Rodriguez, Thomas Fehr, Nilufar Mohebbi, Jens Brockmann, Markus Blum, Nicole Graf, Diana Frey, Rudolf P. Wüthrich   +8 more
doaj   +1 more source

Osteocyte-Driven Bone Remodeling [PDF]

, 2013
Osteocytes, the most abundant cells in bone, have been long postulated to detect and respond to mechanical and hormonal stimuli and to coordinate the function of osteoblasts and osteoclasts.
Bellido, Teresita
core   +1 more source

Connexin 43 Modulates β‐Catenin–Dependent Transcription and Secretory Responses to Oscillatory Fluid Flow in Osteocytes

Journal of Orthopaedic Research, Volume 44, Issue 3, March 2026.
ABSTRACT Osteocytes detect and transduce mechanical cues into biochemical signals that regulate bone remodeling. Connexin 43 (Cx43) is the predominant gap junction protein in osteocytes, but its role in β‐catenin signaling during mechanical loading remains unclear.
Michael A. Friedman, Yue Zhang, Nathanael Neece, Caleb Ryan, Chris Brunkhorst, Henry J. Donahue   +5 more
wiley   +1 more source

Generation and characterization of two immortalized human osteoblastic cell lines useful for epigenetic studies [PDF]

, 2017
Different model systems using osteoblastic cell lines have been developed to help understand the process of bone formation. Here, we report the establishment of two human osteoblastic cell lines obtained from primary cultures upon transduction of ...
A Eddleston, AL Boskey, AR Shakoori, C Lipps, C Rentsch, Carolina Sañudo, CI Westacott, CM Cowan, D Benayahu, D Vanderschueren, Flor M. Pérez-Campo, G Jones, H Ishida, H Sudo, H Tullberg-Reinert, J Delgado-Calle, J Delgado-Calle, J Delgado-Calle, J Delgado-Calle, Jana Arozamena, Jeannette Zauers, Jesús Delgado-Calle, JN Beresford, José A. Riancho, JP Leeuwen van, LG Rao, María T. Berciano, MH Mankani, MH Mankani, Miguel Lafarga, MK Sutherland, MM Wong, MP Whyte, N Maruotti, NK Lee, PV Bodine, SA Harris, SA Stewart, SB Rodan, SH Scharla, T Matsumoto, TJ Shaw, TL Chen, Tobias May, U Valentiner, X Li, Y Suzuki   +46 more
core   +2 more sources

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

Role of bone-anabolic agents in the treatment of breast cancer bone metastases [PDF]

, 2014
Skeletal metastases are an incurable complication afflicting the majority of patients who die from advanced breast cancer. They are most often osteolytic, characterized by net bone destruction and suppressed new bone formation. Life expectancy from first
Chirgwin, John M., Suvannasankha, Attaya
core   +1 more source

Biochemical Responses to Experimentally Induced Short‐Term Low Energy Availability in Athletes: A Systematic Review

Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 3, March 2026.
ABSTRACT Low energy availability (LEA) occurs when dietary energy intake is insufficient to meet the combined demands of exercise and essential physiological functions. Problematic LEA is recognized as the primary driver of Relative Energy Deficiency in Sport (RED‐S), but the short‐term physiological consequences of LEA remain less clearly defined ...
Isabel Guisado‐Cuadrado, Paula Recacha‐Ponce, Ana B. Peinado, Nuria Romero‐Parra   +3 more
wiley   +1 more source

Sclerostin and Wnt Signaling in Idiopathic Juvenile Osteoporosis Using High-Resolution Confocal Microscopy for Three-Dimensional Analyses

Children
Background: Idiopathic juvenile osteoporosis (IJO) is a rare condition characterized by low bone mass that can increase the risk of fractures in children.
Renata C. Pereira, Kathleen J. Noche, Barbara Gales, Zhangying Chen, Isidro B. Salusky, Lauren V. Albrecht   +5 more
doaj   +1 more source

Circulating Sclerostin Levels Are Decreased in Patients with Endogenous Hypercortisolism and Increase after Treatment [PDF]

, 2012
CONTEXT: Increased bone fragility is a frequent complication of hypercortisolism due predominantly to suppression of bone formation. Sclerostin is an osteocyte-produced negative regulator of bone formation, which is up-regulated by glucocorticoids in ...
Eerden, A.W. van der, Hamdy, N.A.T., Heijer, M. den, Hermus, A.R., Lierop, A.H. van, Papapoulos, S.E.   +5 more
core   +1 more source

MECP2 Insufficiency Attenuates RUNX2‐Dependent Osteoblast Differentiation via miR‐126‐3p/DKK1‐Mediated Canonical Wnt Signaling Inhibition in Rett Syndrome

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
MECP2 insufficiency leads to upregulation of miR‐126‐3p, which in turn enhances the endogenous Wnt antagonist DKK1. DKK1 inhibits the canonical Wnt signaling pathway, thereby impairing RUNX2‐dependent osteoblast differentiation. ABSTRACT Rett syndrome (RTT) is a rare neurodevelopmental disorder caused by loss‐of‐function mutations in the gene encoding ...
Shuangshan Dong, Lu Wang, Hiroki Kato, Saki Hirofuji, Zhiyan Zhou, Yosuke Ito, Yuta Hirofuji, Hiroshi Sato, Takahiro A. Kato, Yasunari Sakai, Shouichi Ohga, Satoshi Fukumoto, Keiji Masuda   +12 more
wiley   +1 more source