Results 141 to 150 of about 25,148 (309)
The FASEB Journal, Volume 40, Issue 4, 28 February 2026.Postmenopausal osteoporosis (PMOP) is increasingly recognized as an aging‐associated, multisystem state of fragility, in which estrogen deficiency exacerbates immune and metabolic drift across the bone marrow, skeletal muscle, adipose tissue, gut, vascular system, and neural circuits.
Xianlin Rao, Xiaoyu Cai
wiley +1 more source
Sclerostin and Its Involvement in the Pathogenesis of Idiopathic Scoliosis [PDF]
, 2021 Elias Vasiliadis +4 more
openalex +1 more source
Author response for "Sclerostin protects against vascular calcification development in mice"
, 2022 Annelies De Maré +4 more
openalex +1 more source
Reversal of loss of bone mass in old mice treated with mefloquine [PDF]
, 2018 Aging is accompanied by imbalanced bone remodeling, elevated osteocyte apoptosis, and decreased bone mass and mechanical properties; and improved pharmacologic approaches to counteract bone deterioration with aging are needed.
Allen, Matthew R. +8 more
core +1 more source
PLoS ONE, 2020 It is known that Wnt/β-catenin signaling induces endochondral ossification and plays a significant role in the pathophysiology of osteoarthritis (OA). Sclerostin is a potent inhibitor of the Wnt/β-catenin signaling pathway.
Kazuma Miyatake +4 more
doaj +1 more source
Co-expression of DKK-1 and Sclerostin in Subchondral Bone of the Proximal Femoral Heads from Osteoarthritic Hips [PDF]
, 2017 Osteoarthritis (OA) is a progressively degenerative joint disease influenced by structural and metabolic factors. There is growing evidence that subchondral bone is involved in both symptomatic and structural progression in OA.
Afsie Sabokbar +3 more
core +2 more sources
Serum Osteocalcin, Sclerostin and Lipocalin-2 Levels in Adolescent Boys with Obesity over a 12-Week Sprint Interval Training [PDF]
, 2023 Marit Salus +8 more
openalex +1 more source
BMC Nephrology, 2018 Background Previous clinical studies found inconsistent relationship between circulating sclerostin levels and treatment outcome in patients undergoing maintenance hemodialysis (MHD).
Aiqun Chen +6 more
doaj +1 more source
Genetic evidence that SOST inhibits WNT signaling in the limb [PDF]
, 1987 SOST is a negative regulator of bone formation, and mutations in human SOST are responsible for sclerosteosis. In addition to high bone mass, sclerosteosis patients occasionally display hand defects, suggesting that SOST may function embryonically.
Collette, Nicole M. +4 more
core +1 more source
PTHrP-Derived Peptides Restore Bone Mass and Strength in Diabetic Mice: Additive Effect of Mechanical Loading [PDF]
, 2016 There is an unmet need to understand the mechanisms underlying skeletal deterioration in diabetes mellitus (DM) and to develop therapeutic approaches to treat bone fragility in diabetic patients.
Allen, Matthew R. +9 more
core +1 more source