Results 121 to 130 of about 8,423 (186)

Motor Cortex Hyperexcitability Is Coupled to Neuromuscular Dysfunction in Aged Mice

Aging Cell, Volume 25, Issue 10, October 2026.
Aged mice exhibited impaired motor behavior and neuromuscular hypoexcitability, yet cortical output to muscle was enhanced, and motor cortex layer V pyramidal neurons were hyperexcitable, with altered synaptic inputs and excitability‐related transcriptional changes.
Jose A. Viteri, Nathan R. Kerr, Fereshteh B. Darvishi, Anna Roshani Dashtmian, Charles D. Brennan, Sindhuja N. Ayyagari, Peter J. Moore, Meifang Wang, Harper Snyder, Baocong Yu, Joseph M. Santin, W. David Arnold   +11 more
wiley   +1 more source

Novel Association between SCN1A Mutation and Central Sleep Apnea: A Case of Basilar-Type Migraine

Case Reports in Clinical Practice
We report a 37-year-old woman with recurrent episodes of excessive daytime sleepiness, bizarre behavior, social delays, and confusion lasting 3–5 days. Between episodes, she experienced only mild migraine-like headaches.
Nazanin Esmaeili, Arian Hasani, Tayebeh Salehnezhad, Hamed Amirifard   +3 more
doaj   +1 more source

Brain expression profiles of two SCN1A antisense RNAs in children and adolescents with epilepsy

Objective Heterozygous mutations within the voltage-gated sodium channel α subunit ( SCN1A ) are responsible for the majority of cases of Dravet syndrome (DS), a severe developmental and epileptic encephalopathy.
Metzger, Friedrich, Heinen, Florian, Coras, Roland, Kremer, Thomas, Lugert, Sebastian, Müller, Veronika, Noachtar, Soheyl, Fischer-Hentrich, Antje H. L., Scheuermann, Johanna, Vollmar, Christian, Kunz, Mathias, Tonn, Jörg Christian, Klein, Christoph, Hartlieb, Till, Pace, Claudia, Borggraefe, Ingo, Schneider, Marius Frederik, Vogt, Miriam, Potschka, Heidrun, Kudernatsch, Manfred, Kluger, Gerhard, Blümcke, Ingmar   +21 more
core   +1 more source

Seizures in children with Dravet syndrome in extreme heat: A qualitative study of parental perspectives

Developmental Medicine &Child Neurology, Volume 68, Issue 10, Page 1450-1459, October 2026.
Perspectives of parents of children with Dravet syndrome indicate that extreme heat and high temperatures exacerbate epileptic seizures, introduce new seizure triggers, and require the adoption of specific seizure‑management strategies. This original article is commented by Hood on pages 1338–1339 of this issue.
Angel Aledo‐Serrano, José Ángel Aibar, Domingo Palacios‐Ceña, Maria Salcedo‐Perez‐Juana, Maria Palacios‐Ceña, Simona Giorgi, Manuel Lorenzo‐Dieguez, Sanjay M Sisodiya, Cristina García‐Bravo   +8 more
wiley   +1 more source

Crisis epilépticas en niños con síndrome de Dravet en condiciones de calor extremo: estudio cualitativo de la perspectiva de los progenitores

Developmental Medicine &Child Neurology, Volume 68, Issue 10, Page e168-e178, October 2026.
Resumen Objetivo Describir la experiencia de progenitores de niños y adolescentes con síndrome de Dravet en relación con el impacto de las olas de calor o las altas temperaturas ambientales en las crisis epilépticas de sus hijos, así como las estrategias de afrontamiento empleadas.
Angel Aledo‐Serrano, José Ángel Aibar, Domingo Palacios‐Ceña, Maria Salcedo‐Perez‐Juana, Maria Palacios‐Ceña, Simona Giorgi, Manuel Lorenzo‐Dieguez, Sanjay M Sisodiya, Cristina García‐Bravo   +8 more
wiley   +1 more source

Developmental progression of respiratory dysfunction in a mouse model of Dravet syndrome

JCI Insight
Dravet syndrome (DS) is an early-onset epilepsy caused by loss-of-function mutations in the SCN1A gene, which encodes Nav1.1 channels that preferentially regulate activity of inhibitory neurons early in development. DS is associated with a high incidence
Brenda M. Milla, Eliandra N. da Silva, Cleyton R. Sobrinho, Monica L. Strain, Daniel K. Mulkey   +4 more
doaj   +1 more source

cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsy. [PDF]

Nat Neurosci
Huang Y, Fan L, Wong MY, Lei Z, Krishnamachary B, Zhu D, Cadiz MP, Nagiri RK, Ye P, Norman K, Bhagwat M, Lee YJ, Li H, Zhu J, Amin S, Lauderdale K, Chen H, Luo W, Gong S, Liechty BL, Palop JJ, Sinha SC, Wu J, Zhao M, Gan L.   +24 more
europepmc   +1 more source

Age-dependent axonal dysfunctions and altered sharp-wave ripple oscillations in <i>Scn1a</i> ^<i>+/-</i> mice. [PDF]

iScience
Lascorz R, Roth FC.
europepmc   +1 more source

From targeted SCN1A analysis to whole exome sequencing: clinical utility and novel genetic findings in a Hungarian paediatric epilepsy cohort. [PDF]

Hum Genet
Szalai R, Till A, Galimurka K, Banfai Z, Zsigmond A, Hadzsiev K.   +5 more
europepmc   +1 more source

A Streamlined Workflow for Purkinje Cell Labeling and High-Resolution Analyses of Dendrites and Spines in Mice. [PDF]

eNeuro
Tan X, Niu S, Bai M, Megagiannis P, Suresh R, Pilianidis E, Niibori Y, Hampson DR, Durcan TM, Zhou Y.   +9 more
europepmc   +1 more source