Rho Family GTPases and Rho GEFs in Glucose Homeostasis [PDF]
Cells, 2021 Dysregulation of glucose homeostasis leading to metabolic syndrome and type 2 diabetes is the cause of an increasing world health crisis. New intriguing roles have emerged for Rho family GTPases and their Rho guanine nucleotide exchange factor (GEF ...
Polly A. Machin +3 more
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Genetic epilepsy with febrile seizures plus (GEFS+) [PDF]
Эпилепсия и пароксизмальные состояния, 2020 Febrile seizures (FS) occur in about 2–3% of children aged 3 months to 5 years. Atypical febrile seizures are those with a focal component. Each subsequent febrile attack increases the risk of transformation into epilepsy. After the third febrile seizure,
A. A. Sharkov
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Fenfluramine in SCN1A‐related GEFS+: A multicenter observational study on efficacy, EEG improvement, and tolerability [PDF]
Epilepsia OpenThe SCN1A gene is implicated in a broad spectrum of epilepsy phenotypes, ranging from self‐limited genetic epilepsy with febrile seizures plus (GEFS+) to severe developmental and epileptic encephalopathies such as Dravet syndrome (DS). While fenfluramine
Giovanni B. Dell'Isola +12 more
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Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets [PDF]
MedCommGuanine nucleotide exchange factors (GEFs) and their small GTPase substrates constitute a fundamental regulatory system that governs diverse cellular processes, including cytoskeletal dynamics, membrane trafficking, and transcriptional regulation.
Zexing Lin +15 more
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Genetic epilepsy with febrile seizures plus – an overview [PDF]
Romanian Journal of Neurology, 2021 Genetic epilepsy with febrile seizures plus (GEFS+) is characterized by a group of genetic epilepsies associated predominately with an autosomal dominant pattern, but also with de novo and autosomal-recessive inheritance, these last two found in a small ...
Madalina Radu +3 more
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Ensemble streamflow prediction considering the influence of reservoirs in Narmada River Basin, India [PDF]
Hydrology and Earth System Sciences, 2022 Developing an ensemble hydrological prediction system is essential for reservoir operations and flood early warning. However, efforts to build hydrological ensemble prediction systems considering the influence of reservoirs have been lacking in India. We
U. Vegad, V. Mishra, V. Mishra
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Exaggerated Nighttime Sleep and Defective Sleep Homeostasis in a Drosophila Knock-In Model of Human Epilepsy. [PDF]
PLoS ONE, 2015 Despite an established link between epilepsy and sleep behavior, it remains unclear how specific epileptogenic mutations affect sleep and subsequently influence seizure susceptibility. Recently, Sun et al.
Emily Petruccelli +2 more
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Association of Tumor Necrosis Factor-α Gene Promotor Variant, Not Interleukin-10, with Febrile Seizures and Genetic Epilepsy with Febrile Seizure Plus [PDF]
Annals of Child Neurology, 2019 Purpose Cytokines demonstrate active roles in the occurrence of febrile seizures (FS). However, whether a genetic predisposition to inflammation is implicated in FS, febrile seizure plus (FS+) or genetic epilepsy with febrile seizure plus (GEFS+) are ...
Jieun Choi +9 more
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Frontiers in Cardiovascular Medicine, 2022 Atherosclerosis is a leading cause of cardiovascular disease, and atherosclerotic cardiovascular disease accounts for one-third of global deaths. However, the mechanism of atherosclerosis is not fully understood.
Mengqi Li +9 more
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In Vitro Genotoxicity Evaluation of PAHs in Mixtures Using Experimental Design
Toxics, 2023 Settled dusts are sinks for environmental pollutants, including Polycyclic Aromatic Hydrocarbons (PAHs) that are ubiquitous, persistent, and carcinogenic.
Rebecca Castel +4 more
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