Results 1 to 10 of about 36,093 (252)
Mechanism of Gzma‐mediated GEF‐H1 activation in intestinal epithelial cells leading to intestinal barrier dysfunction in sepsis [PDF]
Clinical and Translational MedicineBackground Sepsis‐induced intestinal injury is a severe complication associated with dysfunction affecting multiple organ systems and a significantly elevated risk of death.
Zexing Lin +18 more
doaj +2 more sources
Cell Reports, 2019 Summary: Dendritic cell (DC) activation is a critical step for anti-tumor T cell responses. Certain chemotherapeutics can influence DC function. Here we demonstrate that chemotherapy capable of microtubule destabilization has direct effects on DC ...
Kea Martin +2 more
exaly +3 more sources
MRCKα Is a Suppressor of GEF-H1/RhoA/MRTF Signaling in Tubular Cells [PDF]
CellsTubule-derived pro-fibrotic mediators are central for the development of kidney fibrosis. We previously showed that fibrotic stimuli activate and elevate GEF-H1 (ARHGEF2) in tubular cells, leading to RhoA-dependent fibrotic reprogramming.
Veroni S. Sri Theivakadadcham +7 more
doaj +2 more sources
PRACTICAL IMPLEMENTATION OF PHOTOGRAMMETRY FOR THE MODELLING OF A CYLINDRICAL HISTORICAL BUILDING [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2023 This work deals with the image capture for close-range photogrammetry in the context of the modelling of a round tower with repetitive texture (made of bricks), both inside and outside.
E. Simonetto +6 more
doaj +1 more source
CORPORATE GOVERNANCE AND POST-MERGER PERFORMANCE: EVIDENCE FROM US BANKS
Copernican Journal of Finance & Accounting, 2021 Mergers operations has currently become one of the key strategies for many firms. It becomes a tool to increase firm value when firm has reached its peak performance. This critical decision expects business performance to improve.The main purpose of this
Amira Neffati +2 more
doaj +3 more sources
ON THE COMBINATION OF PSINSAR AND GNSS TECHNIQUES FOR LONG-TERM BRIDGE MONITORING [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2020 Satellite based monitoring techniques are nowadays an emerging tool for structural health monitoring. In this work, we are interested in the study of the deformations of a cable-stayed bridge using both PsInSAR and GNSS techniques.
A. Nahli +6 more
doaj +1 more source
Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation [PDF]
Open Biology, 2015 RAB18, RAB3GAP1, RAB3GAP2 and TBC1D20 are each mutated in Warburg Micro syndrome, a rare autosomal recessive multisystem disorder. RAB3GAP1 and RAB3GAP2 form a binary ‘RAB3GAP’ complex that functions as a guanine-nucleotide exchange factor (GEF) for ...
Mark T. Handley +6 more
doaj +1 more source
Molecules, 2023 Gefitinib (GEF) is utilized in clinical settings for the treatment of metastatic lung cancer. However, premature drug release from nanoparticles in vivo increases the exposure of systemic organs to GEF.
Abdelrahman Y. Sherif +4 more
doaj +1 more source
Flavoured water consumption alters pharmacokinetic parameters and increases exposure of erlotinib and gefitinib in a preclinical study using Wistar rats [PDF]
PeerJ, 2020 Background Erlotinib (ERL) and Gefitinib (GEF) are considered first line therapy for the management of non-small cell lung carcinoma (NSCLC). Like other tyrosine kinase inhibitors (TKIs), ERL and GEF are mainly metabolized by the cytochrome P450 (CYP450)
Aliyah Almomen +4 more
doaj +2 more sources
Current Opinion in Cell Biology, 2010 Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs), and a family of GTP-hydrolysis activating proteins (GAPs) containing the conserved TBC domain.
Barr, F, Lambright, D
openaire +2 more sources