Results 41 to 50 of about 36,093 (252)

Franquia: Empresário ou consultor | Adm. Sidney Lincoln Vitorino | Blog GEF

, 2018
Artigo técnico profissional realizado pelo Coord. Adm. Sidney l.
GEF Grupo de Excelência em Franquias | CRA-SP (5844560), Sidney Lincoln Vitorino (5707031)   +1 more
core   +1 more source

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

Effects of a gintonin-enriched fraction on hair growth: an in vitro and in vivo study

Journal of Ginseng Research, 2020
Background: Ginseng has been widely used as a health-promoting tonic. Gintonin present in ginseng acts as a lysophosphatidic acid (LPA) receptor ligand that activates six LPA receptor subtypes. The LPA6 subtype plays a key role in normal hair growth, and
Na-Eun Lee, Sang-Deuk Park, Hongik Hwang, Sun-Hye Choi, Ra Mi Lee, Sung Min Nam, Jong Hee Choi, Hyewhon Rhim, Ik-Hyun Cho, Hyoung-Chun Kim, Sung-Hee Hwang, Seung-Yeol Nah   +11 more
doaj   +1 more source

Solid Dispersions of Gefitinib with D-α-Tocopherol Polyethylene Glycol-1000 Succinate and 2-Hydroxypropyl β-Cyclodextrin Complex Improved Their Solubility, Dissolution and Apoptosis against A549 Cells

Applied Sciences, 2023
This study focuses on the development and characterization of solid dispersions (SDs) of Gefitinib (GEF) to improve its aqueous solubility and therapeutic activity against lung cancer.
Mohd Abul Kalam, Adel Ali Alhowyan, Sulaiman S. Alhudaithi, Mohd Shahnawaz Khan, Abdullah K. Alshememry, Musaed Alkholief   +5 more
doaj   +1 more source

Programa de Acção Nacional de Adaptação ás Mudanças Climáticas [PDF]

, 2008
Cabo Verde ratificou a Convenção Quadro das Nações Unidas sobre as Mudanças Climáticas (CQNUMC) a 29 de Março de 1995, e ela entrou em vigor a 22 de Junho do mesmo ano.
GEF, PNUD
core  

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

An Assessment of the Nexus between Good Governance and Economic Growth in Sub-Saharan Africa

Studia Ekonomiczne i Regionalne
This study investigates the nexus between good governance and GDP per capita within Sub-Saharan African countries (SSA), using a dynamic panel data set from 2005 to 2023.
Simba Hamis Miraji, Nyadera Israel Nyaburi   +1 more
doaj   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

GSK-3Beta-Dependent Activation of GEF-H1/ROCK Signaling Promotes LPS-Induced Lung Vascular Endothelial Barrier Dysfunction and Acute Lung Injury

Frontiers in Cellular and Infection Microbiology, 2017
The bacterial endotoxin or lipopolysaccharide (LPS) leads to the extensive vascular endothelial cells (EC) injury under septic conditions. Guanine nucleotide exchange factor-H1 (GEF-H1)/ROCK signaling not only involved in LPS-induced overexpression of ...
Lei Yi, Lei Yi, Xiaoqin Huang, Feng Guo, Zengding Zhou, Mengling Chang, Jingning Huan   +6 more
doaj   +1 more source

Effects of Gintonin-enriched fraction on the gene expression of six lysophosphatidic receptor subtypes

Journal of Ginseng Research, 2021
Background: Gintonin, isolated from ginseng, acts as a ginseng-derived lysophosphatidic acid (LPA) receptor ligand and elicits the [Ca2+]i transient through six LPA receptor subtypes (LPARSs). However, the long-term effects of gintonin-enriched fraction (
Rami Lee, Byung-Hwan Lee, Sun-Hye Choi, Yeon-Jin Cho, Han-Sung Cho, Hyoung-Chun Kim, Hyewhon Rhim, Ik-Hyun Cho, Man Hee Rhee, Seung-Yeol Nah   +9 more
doaj   +1 more source