Results 21 to 30 of about 36,093 (252)
Journal of Ginseng Research, 2023 Background: Ginseng contains three active components: ginsenosides, gintonin, and polysaccharides. After the separation of 1 of the 3 ingredient fractions, other fractions are usually discarded as waste. In this study, we developed a simple and effective
Rami Lee +11 more
doaj +1 more source
Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, is altered in individuals with bipolar disorder. [PDF]
PLoS ONE, 2010 In the rodent forebrain GABAergic neurons are generated from progenitor cells that express the transcription factors Dlx1 and Dlx2. The Rap-1 guanine nucleotide exchange factor, MR-GEF, is turned on by many of these developing GABAergic neurons ...
Angela Bithell +7 more
doaj +1 more source
Pharmaceuticals, 2022 Background: Erlotinib (ERL) and gefitinib (GEF) are extensively metabolized by CYP450 enzymes. Aspartame (ASP), an artificial sweetener, induces CYP2E1 and CYP3A2 enzymes in the brain and could increase liver enzymes.
Hajer AlRasheed +6 more
doaj +1 more source
GEF-effector interactions [PDF]
Cellular Logistics, 2014 Members of the Arf family of small GTP-binding proteins, or GTPases, are activated by guanine nucleotide exchange factors (GEFs) that catalyze GDP release from their substrate Arf, allowing GTP to bind. In the secretory pathway, Arf1 is first activated by GBF1 at the cis-Golgi, then by BIG1 and BIG2 at the trans-Golgi and trans-Golgi network (TGN ...
openaire +2 more sources
Angewandte Chemie, EarlyView.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +2 more sources
Pharmaceutics, 2023 Gefitinib (GEF) is a clinical medication for the treatment of lung cancer targeting the epidermal growth factor receptor (EGFR). However, its efficacy is remarkably limited by low solubility and dissolution rates.
Muhammad Inam +10 more
doaj +1 more source
GEF CReW+ República Dominicana : proyecto de saneamiento de Sabana Yegua
, 2023 El video muestra el proyecto de rehabilitación de la Planta de Tratamiento de Aguas Residuales de Sabana Yegua, liderado por el Ministerio de Medio Ambiente y Recursos Naturales y financiado por el Fondo para el Medio Ambiente Mundial (GEF) en el marco ...
GEF CReW+
core
Platelet Rho GTPase regulation in physiology and disease
Platelets, 2019 Rho GTPases are master orchestrators of cytoskeletal dynamics and serve critical roles in platelet physiology to promote hemostasis or pathology in thrombotic, inflammatory and other disease states.
Joseph E. Aslan
doaj +1 more source
GEF CReW+ República Dominicana : proyecto de saneamiento de la Universidad Autónoma de Santo Domingo
, 2023 El video muestra el proyecto de rehabilitación de la Planta de Tratamiento de Aguas Residuales de la Universidad Autónoma de Santo Domingo (Recinto Santiago), liderado por el Ministerio de Medio Ambiente y Recursos Naturales y financiado por el Fondo ...
GEF CReW+
core
Bioactive lipids in gintonin-enriched fraction from ginseng
Journal of Ginseng Research, 2019 Background: Ginseng is a traditional herbal medicine for human health. Ginseng contains a bioactive ligand named gintonin. The active ingredient of gintonin is lysophosphatidic acid C18:2 (LPA C18:2).
Hee-Jung Cho +7 more
doaj +1 more source