GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses [PDF]
Cell Reports, 2019 Summary: Dendritic cell (DC) activation is a critical step for anti-tumor T cell responses. Certain chemotherapeutics can influence DC function. Here we demonstrate that chemotherapy capable of microtubule destabilization has direct effects on DC ...
Kea Martin +2 more
exaly +4 more sources
GEF-H1 Transduces FcεRI Signaling in Mast Cells to Activate RhoA and Focal Adhesion Formation during Exocytosis [PDF]
Cells, 2023 When antigen-stimulated, mast cells release preformed inflammatory mediators stored in cytoplasmic granules. This occurs via a robust exocytosis mechanism termed degranulation.
Yitian Guo, Judeah Negre, Gary Eitzen
doaj +2 more sources
Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease [PDF]
Cells, 2022 Inflammation and fibrosis are important components of diseases that contribute to the malfunction of epithelia and endothelia. The Rho guanine nucleotide exchange factor (GEF) GEF-H1/ARHGEF-2 is induced in disease and stimulates inflammatory and fibrotic
Clare Mills +11 more
doaj +2 more sources
HUNK inhibits epithelial-mesenchymal transition of CRC via direct phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1 [PDF]
Cell Death and Disease, 2023 Epithelial-mesenchymal transition (EMT) is associated with the invasive and metastatic phenotypes in colorectal cancer (CRC). However, the mechanisms underlying EMT in CRC are not completely understood.
Xiaoqi Han +16 more
doaj +2 more sources
Bartonella effector protein C mediates actin stress fiber formation via recruitment of GEF-H1 to the plasma membrane. [PDF]
PLoS Pathogens, 2021 Bartonellae are Gram-negative facultative-intracellular pathogens that use a type-IV-secretion system (T4SS) to translocate a cocktail of Bartonella effector proteins (Beps) into host cells to modulate diverse cellular functions.
Simon Marlaire, Christoph Dehio
doaj +2 more sources
MRCKα Is a Suppressor of GEF-H1/RhoA/MRTF Signaling in Tubular Cells [PDF]
CellsTubule-derived pro-fibrotic mediators are central for the development of kidney fibrosis. We previously showed that fibrotic stimuli activate and elevate GEF-H1 (ARHGEF2) in tubular cells, leading to RhoA-dependent fibrotic reprogramming.
Veroni S. Sri Theivakadadcham +7 more
doaj +2 more sources
Mechanism of Gzma‐mediated GEF‐H1 activation in intestinal epithelial cells leading to intestinal barrier dysfunction in sepsis [PDF]
Clinical and Translational MedicineBackground Sepsis‐induced intestinal injury is a severe complication associated with dysfunction affecting multiple organ systems and a significantly elevated risk of death.
Zexing Lin +18 more
doaj +2 more sources
Bartonella type IV secretion effector BepC induces stress fiber formation through activation of GEF-H1. [PDF]
PLoS Pathogens, 2021 Bartonella T4SS effector BepC was reported to mediate internalization of big Bartonella aggregates into host cells by modulating F-actin polymerization. After that, BepC was indicated to induce host cell fragmentation, an interesting cell phenotype that ...
Chunyan Wang +9 more
doaj +2 more sources
Keratinocyte-derived VEGF-A is an essential pro-migratory autocrine mediator, acting through the KDR/GEF-H1/RhoA pathway [PDF]
Frontiers in Cell and Developmental BiologyIntroductionKeratinocytes proliferate, migrate and differentiate to achieve skin re-epithelialization following injury. They also secrete soluble mediators to induce inflammation and orchestrate restoration of the skin barrier.
Vida Maksimoska +8 more
doaj +2 more sources
Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes [PDF]
eLife, 2022 Immune synapse formation is a key step for lymphocyte activation. In B lymphocytes, the immune synapse controls the production of high-affinity antibodies, thereby defining the efficiency of humoral immune responses.
Judith Pineau +5 more
doaj +2 more sources