Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5 [PDF]
Nature Communications, 2019 The transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors show that the microtubule-associated factor GEF-H1 plays a critical role in host defense against Listeria monocytogenes in macrophages via activation of ...
Yun Zhao +5 more
doaj +2 more sources
Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma
Biologics: Targets & Therapy, 2016 Jie Shi, Bingyu Guo, Yu Zhang, Qiang Hui, Peng Chang, Kai Tao Reconstructive and Plastic Surgery, The General Hospital of Shenyang Military Region, Shenyang, People’s Republic of China Abstract: Guanine nucleotide exchange ...
Shi J +5 more
doaj +1 more source
Reducing GEF-H1 Expression Inhibits Renal Cyst Formation, Inflammation, and Fibrosis via RhoA Signaling in Nephronophthisis. [PDF]
Int J Mol Sci, 2023 Nephronophthisis (NPHP) is the most prevalent monogenic disease leading to end-stage renal failure in childhood. RhoA activation is involved in NPHP pathogenesis. This study explored the role of the RhoA activator guanine nucleotide exchange factor (GEF)-
Hu Q +6 more
europepmc +2 more sources
GEF-H1 regulates mast cell exocytosis by Guo et al., 2022
, 2022 RBL-2H3 mast cells were imaged during antigen stimulation. Each video represent either control cells (vector shRNA) or GEF-H1 knockdown cells (GEF-H1 shRNA).
Gary Eitzen (12232157) +2 more
core +1 more source
The Y-box factor ZONAB/DbpA associates with GEF-H1/Lfc and mediates Rho-stimulated transcription [PDF]
, 2009 Epithelial tight junctions recruit different types of signalling proteins that regulate cell proliferation and differentiation. Little is known about how such proteins interact functionally and biochemically with each other.
Leefa Chong San, I.V. +9 more
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RhoA regulation by Myo9b and GEF-H1 in platelets [PDF]
, 2020 Background: Circulating platelets are maintained in an inactive state by the endothelial lining of the vasculature. Endothelium-derived prostacyclin and nitric oxide stimulate cAMP- and cGMP-dependent kinases, PKA and PKG, to inhibit platelets.
Smolenski, Albert P. +4 more
core +1 more source
Frontiers in Cellular and Infection Microbiology, 2017 The bacterial endotoxin or lipopolysaccharide (LPS) leads to the extensive vascular endothelial cells (EC) injury under septic conditions. Guanine nucleotide exchange factor-H1 (GEF-H1)/ROCK signaling not only involved in LPS-induced overexpression of ...
Lei Yi +6 more
doaj +1 more source
GEF-H1-RhoA signaling pathway mediates LPS-induced NF-κB transactivation and IL-8 synthesis in endothelial cells [PDF]
, 2012 Secretion of proinflammatory cytokines by LPS activated endothelial cells contributes substantially to the pathogenesis of sepsis. However, the mechanism involved in this process is not well understood. In the present study, we determined the roles of GEF-
Derek Van Lonkhuyzen +13 more
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Optogenetic Tuning Reveals Rho Amplification-Dependent Dynamics of a Cell Contraction Signal Network
Cell Reports, 2020 Summary: Local cell contraction pulses play important roles in tissue and cell morphogenesis. Here, we improve a chemo-optogenetic approach and apply it to investigate the signal network that generates these pulses.
Dominic Kamps +12 more
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Modulation of Endothelial Inflammation by Low and High Magnitude Cyclic Stretch. [PDF]
PLoS ONE, 2016 Excessive mechanical ventilation exerts pathologic mechanical strain on lung vascular endothelium and promotes endothelial cell (EC) inflammatory activation; however, the specific mechanisms underlying EC inflammatory response caused by mechanical ...
Yufeng Tian +4 more
doaj +1 more source