Results 31 to 40 of about 136,869 (147)

NDR2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of RASSF1A tumor-suppressor gene in lung cancer cells

Journal of Experimental & Clinical Cancer Research, 2019
Background RASSF1A, a tumor suppressor gene, is frequently inactivated in lung cancer leading to a YAP-dependent epithelial-mesenchymal transition (EMT). Such effects are partly due to the inactivation of the anti-migratory RhoB GTPase via the inhibitory
Maureen Keller, Fatéméh Dubois, Sylvain Teulier, Alexandre P. J. Martin, Jérôme Levallet, Elodie Maille, Solenn Brosseau, Nicolas Elie, Alexander Hergovich, Emmanuel Bergot, Jacques Camonis, Gérard Zalcman, Guénaëlle Levallet   +12 more
doaj   +1 more source

Fasudil and SR1001 synergistically protect against sepsis-associated pancreatic injury by inhibiting RhoA/ROCK pathway and Th17/IL-17 response

Heliyon, 2023
Sepsis is defined as a dysregulated host response to infection that can result in organ dysfunction and high mortality, which needs more effective treatment urgently. Pancreas is one of the most vulnerable organs in sepsis, resulting in sepsis-associated
Pingping Liu, Zhenghui Xiao, Xiulan Lu, Xinping Zhang, Jiaotian Huang, Cheng Li   +5 more
doaj   +1 more source

Microtubule-Mediated NLRP3 Inflammasome Activation Is Independent of Microtubule-Associated Innate Immune Factor GEF-H1 in Murine Macrophages. [PDF]

Int J Mol Sci, 2020
Inflammasomes are intracellular multiple protein complexes that mount innate immune responses to tissue damage and invading pathogens. Their excessive activation is crucial in the development and pathogenesis of inflammatory disorders.
Lai HJ, Hsu YH, Lee GY, Chiang HS.
europepmc   +2 more sources

Interaction between the type III effector VopO and GEF-H1 activates the RhoA-ROCK pathway. [PDF]

PLoS Pathogens, 2015
Vibrio parahaemolyticus is an important pathogen that causes food-borne gastroenteritis in humans. The type III secretion system encoded on chromosome 2 (T3SS2) plays a critical role in the enterotoxic activity of V. parahaemolyticus.
Hirotaka Hiyoshi, Ryu Okada, Shigeaki Matsuda, Kazuyoshi Gotoh, Yukihiro Akeda, Tetsuya Iida, Toshio Kodama   +6 more
doaj   +1 more source

Drug discovery for inhibition of the GEF-H1/RhoA pathway

, 2023
Fibrosis and inflammation in human tissues are common markers for diseases like epithelial cancers, organ injuries and infections, and common ocular disorders.
Gathmann, Clara
core   +1 more source

Autophagy Induced by Toll-like Receptor Ligands Regulates Antigen Extraction and Presentation by B Cells

Cells, 2022
The engagement of B cells with surface-tethered antigens triggers the formation of an immune synapse (IS), where the local secretion of lysosomes can facilitate antigen uptake.
Jonathan Lagos, Sara Sagadiev, Jheimmy Diaz, Juan Pablo Bozo, Fanny Guzman, Caroline Stefani, Silvana Zanlungo, Mridu Acharya, Maria Isabel Yuseff   +8 more
doaj   +1 more source

GEF-H1 Modulates Localized RhoA Activation during Cytokinesis under the Control of Mitotic Kinases [PDF]

, 2007
SummaryFormation of the mitotic cleavage furrow is dependent upon both microtubules and activity of the small GTPase RhoA. GEF-H1 is a microtubule-regulated exchange factor that couples microtubule dynamics to RhoA activation.
Nalbant, Perihan, Jörg Birkenfeld, Bokoch, Gary M., Olivier Pertz, Klaus M. Hahn, Pertz, Olivier, Bohl, Benjamin P., Perihan Nalbant, Benjamin P. Bohl, Gary M. Bokoch, Hahn, Klaus M., Birkenfeld, Jörg   +11 more
core   +1 more source

Cytoskeletal Remodeling and Exocytosis During Mast Cell Activation is Controlled by the RhoA GEF, GEF-H1 [PDF]

, 2021
Mast cells are tissue-resident immune cells that play important roles in health and diseases. Mast cells release their granule contents under antigen-stimulation via the FcεRI signaling pathway.
Guo, Yitian
core   +1 more source

GEF CReW+ República Dominicana : proyecto de saneamiento de Sabana Yegua

, 2023
El video muestra el proyecto de rehabilitación de la Planta de Tratamiento de Aguas Residuales de Sabana Yegua, liderado por el Ministerio de Medio Ambiente y Recursos Naturales y financiado por el Fondo para el Medio Ambiente Mundial (GEF) en el marco ...
GEF CReW+
core  

Protective effects of resveratrol and SR1001 on hypoxia-induced pulmonary hypertension in rats

Clinical and Experimental Hypertension, 2020
Hypoxic pulmonary hypertension (HPH) is a fatal disease with limited therapeutic strategies. Combination therapy is regarded as the standard of care in PH and becoming widely used in clinical practice.
Cheng Li, Ganlin Peng, Jing Long, Pan Xiao, Xiaoyuan Zeng, Hongzhong Yang   +5 more
doaj   +1 more source