Results 41 to 50 of about 136,869 (147)

GEF CReW+ República Dominicana : proyecto de saneamiento de la Universidad Autónoma de Santo Domingo

, 2023
El video muestra el proyecto de rehabilitación de la Planta de Tratamiento de Aguas Residuales de la Universidad Autónoma de Santo Domingo (Recinto Santiago), liderado por el Ministerio de Medio Ambiente y Recursos Naturales y financiado por el Fondo ...
GEF CReW+
core  

Contribution of guanine exchange factor H1 in phorbol ester-induced apoptosis

, 2008
Phorbol-12-myristate-13-acetate (PMA) treatment induces erythroblastoma D2 cells kept in suspension to undergo RhoA-dependent contraction and to become proapoptotic, while attached cells are induced to differentiate accompanied by the reduction of RhoA ...
李宏孝, 張智芬
core   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

GEF-H1 mediates RhoA dependent NF-κB activation.

, 2013
(A) GEF-H1 mediated NF-κB reporter gene expression in the absence or presence of dominant negative RhoA (T19N) or the ROCK inhibitor Y27632 in HEK293.
Beth Ann McCormick (375745), Atsuko Fukazawa (375740), Kiyotaka Kurachi (375742), Sonal Gupta (375743), Carmen Alonso (375741), Cammie F. Lesser (375744), Hans-Christian Reinecker (375747)   +6 more
core   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Governing Artificial Intelligence and Digital Economy for Sustainability: Does Institutional Quality Help or Hinder SDGs Progress Across OECD Countries?

Business Strategy and the Environment, EarlyView.
ABSTRACT This study investigates how artificial intelligence (AI) can support sustainable development strategies in OECD countries, particularly in achieving the United Nations Sustainable Development Goals (SDGs). The study contributes to the literature by investigating the role of AI as a transformative enabler of sustainable business strategies ...
Muskan Sahu, Waleed M. Alahdal, Mohammed M. Elgammal   +2 more
wiley   +1 more source

Fluid shear stress activates YAP to promote epithelial–mesenchymal transition in hepatocellular carcinoma

Molecular Oncology, 2021
Epithelial–mesenchymal transition (EMT) mediated by fluid shear stress (FSS) in the tumor microenvironment plays an important role in driving metastasis of the malignant tumor.
Hongchi Yu, Jia He, Guanyue Su, Yuelong Wang, Fei Fang, Wenxing Yang, Kaiyun Gu, Naiyang Fu, Yunbing Wang, Yang Shen, Xiaoheng Liu   +10 more
doaj   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

How Is FinTech Shaping Household Portfolio Behaviour?

International Journal of Finance &Economics, EarlyView.
ABSTRACT This paper examines how FinTech adoption influences household portfolio allocation across major advanced economies. Using a flow‐of‐funds framework and the Almost Ideal Demand System (AIDS), we model household demand for currency, deposits, loans, debt securities, and equity in the United States, United Kingdom, Euro Area, Japan and Australia.
Victor Murinde, Athina Petropoulou
wiley   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source