Results 51 to 60 of about 136,869 (147)

MARK2 serves as a key regulator of host antiviral immunity through GEF-H1 phosphorylation

Cell Reports
Summary: The innate immune system detects viral infections and mounts robust type I interferon (IFN-I) responses to establish antiviral defenses. However, the regulatory mechanisms that control the amplitude and duration of IFN-I signaling remain ...
Kezhen Wang, Linchao Li, Yanan Li, Xue Zhu, Wenbiao Peng, Luoxue Hua, Zifan Zhuang, Xiaoye Yang, Guoshuai Zhu, Junjie Li, Jun Cao, Sidong Xiong, Gefei Chen, Xingmei Qi   +13 more
doaj   +1 more source

Cytoskeletal Dynamics in Cancer: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 10, October 2026.
This review systematically addresses the fundamental roles of the cytoskeleton (actin filaments, microtubules, and intermediate filaments) in cancer progression. We focus on how cytoskeletal dynamics regulate tumor proliferation, metastasis, and programmed cell death, while also modulating the immune microenvironment. Understanding these mechanisms may
Jie Chen, Wenxi Yang, Yonghan Song, Yuanhao Zhang, Jia Ma, Tingyao Wang, Jijun Zheng, Hebin Zhang, Yiyao Liu, Jinhao Zeng   +9 more
wiley   +1 more source

Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells

BMC Cancer, 2012
Background Anti-cancer drugs are widely used in cancer treatment frequently combined with surgical therapy and/or radiation therapy. Although surgery and radiation have been suggested to facilitate invasion and metastasis of tumor cells in some cases ...
Eitaki Masato, Yamamori Tohru, Meike Shunsuke, Yasui Hironobu, Inanami Osamu   +4 more
doaj   +1 more source

The RhoA dependent anti-metastatic function of RKIP in breast cancer

Scientific Reports, 2021
Raf-1 kinase inhibitor protein was initially discovered as a physiological kinase inhibitor of the MAPK signaling pathway and was later shown to suppress cancer cell invasion and metastasis.
Gardiyawasam Kalpana, Christopher Figy, Jingwei Feng, Claire Tipton, Julius N. De Castro, Vu N. Bach, Clariza Borile, Alexandria LaSalla, Hussain N. Odeh, Miranda Yeung, Rafael Garcia-Mata, Kam C. Yeung   +11 more
doaj   +1 more source

Can Green Energy Finance and Eco‐Friendly Taxes Cap Global Warming to 2 Degrees and 1.5 Degrees Celsius Above Pre‐Industrial Levels? Uncovering the Synergistic Power of Rule of Law

World Affairs, Volume 189, Issue 4, Winter 2026.
ABSTRACT Anchored on the sustainable development goals (SDGs) and the Paris Agreement, which seek to limit the global average temperature to well below 2°C above pre‐industrial levels and pursue efforts to limit the temperature to 1.5°C, this study investigates how green energy finance and environmental taxes affect environmental quality, with an ...
Mohammed Musah, Isaac Adjei Mensah, Thomas Appiah, Kwadwo Boateng Prempeh, Simplice A. Asongu   +4 more
wiley   +1 more source

CORO1C, a novel PAK4 binding protein, recruitsphospho-PAK4 at serine 99 to the leading edge and promotes the migration of gastric cancer cells

Acta Biochimica et Biophysica Sinica, 2022
Gastric cancer is one of the malignant tumors in the world. PAK4 plays an important role in the occurrence and development of gastric cancer, especially in the process of invasion and metastasis.
Li Xiaodong, Chen Min, Yuan Ying, Li Jiabin, Li Feng   +4 more
doaj   +1 more source

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, Volume 13, Issue 52, 18 September 2026.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

Microtubule and Actin Interplay Drive Intracellular c-Src Trafficking.

PLoS ONE, 2016
The proto-oncogene c-Src is involved in a variety of signaling processes. Therefore, c-Src spatiotemporal localization is critical for interaction with downstream targets.
Christopher Arnette, Keyada Frye, Irina Kaverina   +2 more
doaj   +1 more source

RhoB regulates cell migration through altered focal adhesion dynamics [PDF]

Open Biology, 2012
The Rho GTPase RhoB has been shown to affect cell migration, but how it does this is not clear. Here we show that cells depleted of RhoB by RNAi are rounded and have defects in Rac-mediated spreading and lamellipodium extension, although they have active
Francisco M. Vega, Audrey Colomba, Nicolas Reymond, Mairian Thomas, Anne J. Ridley   +4 more
doaj   +1 more source

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis. [PDF]

Sci Rep, 2016
Structural cardiac remodeling, accompanying cytoskeletal reorganization of cardiac cells, is a major clinical outcome of diastolic heart failure. A highly local Ca2+ influx across the plasma membrane has been suggested to code signals to induce Rho ...
Numaga-Tomita T, Kitajima N, Kuroda T, Nishimura A, Miyano K, Yasuda S, Kuwahara K, Sato Y, Ide T, Birnbaumer L, Sumimoto H, Mori Y, Nishida M.   +12 more
europepmc   +2 more sources