Results 71 to 80 of about 136,869 (147)

The Edwardsiella T3SS effector EseQ promotes invasion by altering the cell’s cytoskeleton and disrupting the epithelial barrier

mSphere
Edwardsiella piscicida is a Gram-negative, intracellular, enteric pathogen that primarily causes hemorrhagic septicemia in fish. It survives and replicates within host cells by delivering a subset of effector proteins via the type III secretion system ...
Xiu Long Jiang, Tian Tian He, Pu Yu Tang, Qin Wang, Pin Nie, Hai Xia Xie   +5 more
doaj   +1 more source

T1R3 homomeric sweet taste receptor regulates adipogenesis through Gαs-mediated microtubules disassembly and Rho activation in 3T3-L1 cells. [PDF]

PLoS ONE, 2017
We previously reported that 3T3-L1 cells express a functional sweet taste receptor possibly as a T1R3 homomer that is coupled to Gs and negatively regulates adipogenesis by a Gαs-mediated but cAMP-independent mechanism.
Yosuke Masubuchi, Yuko Nakagawa, Johan Medina, Masahiro Nagasawa, Itaru Kojima, Mark M Rasenick, Takeshi Inagaki, Hiroshi Shibata   +7 more
doaj   +1 more source

GEF-H1 mediates RhoA activation during S. flexneri cell invasion.

, 2013
(A) Western blot analysis of subcellular distribution of GEF-H1 and cingulin upon S. flexneri invasion of MDCK cell monolayer. Densitometric analysis of GEF-H1 and cingulin in soluble and insoluble protein fractions during Shigella infection.
Beth Ann McCormick (375745), Atsuko Fukazawa (375740), Kiyotaka Kurachi (375742), Sonal Gupta (375743), Carmen Alonso (375741), Cammie F. Lesser (375744), Hans-Christian Reinecker (375747)   +6 more
core   +1 more source

PPP2R3C serves as a negative regulator associated with reduced T cell hyperactivation and renal protection in lupus

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Downregulation of PPP2R3C in lupus CD4+ T cells unleashes JNK/c‑Jun and PLCγ1 signalling, driving calcium influx and inflammatory cytokine production. Reconstitution of PPP2R3C expression curbs T cell activation, lowers autoantibody levels and alleviates lupus nephritis, highlighting PPP2R3C as a promising therapeutic candidate. Abstract Background CD4+
Xuan Fang, Yi Qin, Jinhui Tao, Zhou Zhou, Minglong Cai, Hong Zhang, Xiangpei Li, Xiaomei Li, Zhu Chen   +8 more
wiley   +1 more source

GEF-H1 interacts with NOD1 and is required for NOD1 dependent NF-κB activation.

, 2013
(A) NF-κB activation in response to active and inactive NOD1 ligands in the absence or presence of GEF-H1 and NOD1 siRNA in HEK293 cells.
Beth Ann McCormick (375745), Atsuko Fukazawa (375740), Kiyotaka Kurachi (375742), Sonal Gupta (375743), Carmen Alonso (375741), Cammie F. Lesser (375744), Hans-Christian Reinecker (375747)   +6 more
core   +1 more source

GEF-H1, a VopO binding partner, is necessary for VopO-induced stress fiber formation.

, 2015
(A) Identification of GEF-H1 as a VopO binding partner using a GST pull-down assay. Purified GST-VopO was mixed with a HeLa cell lysate, and the proteins retained on the glutathione beads were separated by SDS-PAGE.
Yukihiro Akeda (240105), Ryu Okada (698406), Kazuyoshi Gotoh (240089), Hirotaka Hiyoshi (240093), Shigeaki Matsuda (150159), Tetsuya Iida (150175), Toshio Kodama (150168)   +6 more
core   +1 more source

Cell Mechanics in Cancer: Integrating Mechanotransduction Pathways Within the Tumor Microenvironment

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
ABSTRACT Single‐cell mechanical properties such as stiffness, elasticity, and viscosity, are crucial in governing biological processes like migration, proliferation, and differentiation. In cancer, the mechanical properties of cells undergo significant alterations, which contribute to tumor growth, metastasis, and resistance to therapy.
Merve Sevgi, Yağmur Işık, Caner Karaca, Esmahan Çağlar, Hasan Berkay Abdioğlu, Ferican Zendel, Yasemin Başbınar, Hüseyin Üvet   +7 more
wiley   +1 more source

Structural and functional insights into TBC1D17 highlight the importance of the previously uncharacterized Rab‐binding domain

Protein Science, Volume 35, Issue 5, May 2026.
Abstract TBC (Tre2/Bub2/Cdc16) domain‐containing proteins constitute the widespread family of GTPase‐activating proteins (GAPs). They interact with the Rab superfamily of small GTPases, stimulate GTP hydrolysis, and regulate vesicle trafficking. TBC1D17, involved in Shiga toxin trafficking, autophagy and glucose metabolism regulation, constitutes an ...
Dominika Nielipińska, Marta Orlikowska, Maciej Nielipiński, Bartosz Sekuła, Katarzyna M. Błażewska, Edyta Gendaszewska‐Darmach, Agnieszka J. Pietrzyk‐Brzezińska   +6 more
wiley   +1 more source

Bves modulates tight junction associated signaling.

PLoS ONE, 2011
Blood vessel epicardial substance (Bves) is a transmembrane adhesion protein that regulates tight junction (TJ) formation in a variety of epithelia. The role of TJs within epithelium extends beyond the mechanical properties.
Patricia K Russ, Christopher J Pino, Christopher S Williams, David M Bader, Frederick R Haselton, Min S Chang   +5 more
doaj   +1 more source

A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesions

eLife, 2018
Protein kinase D (PKD) is a family of serine/threonine kinases that is required for the structural integrity and function of the Golgi complex. Despite its importance in the regulation of Golgi function, the molecular mechanisms regulating PKD activity ...
Stephan A Eisler, Filipa Curado, Gisela Link, Sarah Schulz, Melanie Noack, Maren Steinke, Monilola A Olayioye, Angelika Hausser   +7 more
doaj   +1 more source