Results 91 to 100 of about 136,869 (147)

Effect of chronic CS preconditioning on GEF-H1 expression.

, 2016
(A) HPAEC were subjected to 18% CS for 48 or 72 hours, or left under static conditions. Stretch-induced time-dependent expression of GEF-H1 was monitored by immunoblotting with corresponding antibodies.
Anna A. Birukova (333901), Isa Mambetsariev (553195), James J. O'Donnell III (2634892), Grzegorz Gawlak (2465860), Yufeng Tian (343868)   +4 more
core   +1 more source

Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets

MedComm
Guanine nucleotide exchange factors (GEFs) and their small GTPase substrates constitute a fundamental regulatory system that governs diverse cellular processes, including cytoskeletal dynamics, membrane trafficking, and transcriptional regulation.
Zexing Lin, Chujun Ni, Haiyang Jiang, Huan Yang, Liting Deng, Peizhao Liu, Xuanheng Li, Yilong Yu, Weijie Li, Runnan Wang, Bo Liao, Jiaqi Kang, Juanhan Liu, Xiuwen Wu, Jianan Ren, Yun Zhao   +15 more
doaj   +1 more source

Structural Basis of Microtubule-regulated “Sequestration and Release” of GEF-H1 in Signal Transduction

Shengwu huaxue yu shengwu wuli jinzhan
Microtubules have long been regarded as structural scaffolds that maintain cell shape, mediate intracellular transport, and drive cell division. Over the past two decades, this view has shifted, with accumulating evidence demonstrating that microtubules ...
REN Jin-Qi
doaj   +1 more source

Guanine nucleotide exchange factors and colon neoplasia

Frontiers in Cell and Developmental Biology
Despite many diagnostic and therapeutic advances, colorectal cancer (CRC) remains the second leading cause of cancer death for men and women in the United States.
Lea-Pearl Njei, Natalia Sampaio Moura, Alyssa Schledwitz, Kelly Griffiths, Kunrong Cheng, Jean-Pierre Raufman, Jean-Pierre Raufman, Jean-Pierre Raufman, Jean-Pierre Raufman   +8 more
doaj   +1 more source

Fidgetin-like 2 depletion enhances cell migration by regulating GEF-H1, RhoA, and FAK. [PDF]

Biophys J, 2023
Smart K, Kramer AH, Smart S, Hodgson L, Sharp DJ.   +4 more
europepmc   +1 more source

Regulation of RhoA signaling by GEF-H1 in cell fate and migration

, 2010
RhoA是多種訊息傳遞的中樞，而懸浮性的骨髓細胞常含有高量的活化態RhoA。當D2細胞受PMA刺激時，可誘使半數細胞RhoA活性降低並貼附於培養皿而分化成類單核球/巨噬細胞球樣的形態，另一部分維持懸浮狀態的細胞則仍具有高的RhoA活性但卻走向凋亡途徑。由於D2細胞在受到PMA誘發而走向分化或凋亡命運，與RhoA活性高低息息相關，故此研究旨在探討PMA誘發的分化及凋亡的細胞中，調控RhoA活性的機制。我在D2細胞中找到具有和RhoA專一性結合的GEF-H1蛋白，此具有活化RhoA的GEF ...
Chang, Yuan-Chen, 張元貞
core  

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

ePoster

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Erratum: Hypoxia induced exosomal circRNA promotes metastasis of Colorectal Cancer via targeting GEF-H1/RhoA axis: Erratum. [PDF]

Theranostics, 2022
Yang H, Zhang H, Yang Y, Wang X, Deng T, Liu R, Ning T, Bai M, Li H, Zhu K, Li J, Fan Q, Ying G, Ba Y.   +13 more
europepmc   +1 more source

Effect of substrate stiffness and LOX inhibition on LPS-induced GEF-H1 expression.

, 2014
A - Pulmonary EC were grown on polyacrylamide gels of different stiffness (1.5 kPa, and 40 kPa) and treated with LPS (200 ng/ml) for 6 hrs. GEF-H1 expression determined by western blot analysis. Bar graphs depict the quantitative analysis of western blot
Anna A. Birukova (333901), Isa Mambetsariev (553195), Tera Lavoie (553196), Tinghuai Wu (333907), Julian Solway (188617), Konstantin G. Birukov (333911), Yufeng Tian (343868)   +6 more
core   +1 more source