Results 81 to 90 of about 136,869 (147)
Respiratory Research, 2018 Background Endothelial barrier dysfunction is central to the pathogenesis of sepsis-associated acute lung injury (ALI). Microtubule (MT) dynamics in vascular endothelium are crucial for the regulation of endothelial barrier function.
Shengtian Mu +6 more
doaj +1 more source
Inhibition of the Rho signalling activator GEF-H1 for the prevention of epithelial degeneration
, 2017 Pathological responses, involving the degeneration and malfunction of epithelial tissue, are major components of many clinically relevant diseases. In the eye, such epithelial degeneration is an important component of pathologies affecting the retinal ...
Mills, CC
core +1 more source
GEF-H1 is recruited into membrane ruffles induced by S. flexneri.
, 2013 XY, XZ and YZ sections as well as three-dimensional reconstructions (volume render) of confocal image series of GEF-H1 recruitment to the invasion sites of S. flexneri.
Beth Ann McCormick (375745) +6 more
core +1 more source
Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
GEF-H1 drives tumor formation, motility, invasion and metastasis in breast cancer
, 2021 RhoGTPases family are involved in several biological process including gene transcription, cell polarity, migration and invasion. RhoGTPases switch between on and off states and they are regulated by several GEFs (activators) and GAPs/RhoGDIs ...
Fernández Chávez, Lucía +5 more
core +1 more source
Gef-H1 Couples Nocodazole-Induced Microtubule Disassembly to Cell Contractility Via Rhoa
, 2009 The RhoA GTPase plays a vital role in assembly of contractile actin- myosin filaments (stress fibers) and of associated focal adhesion complexes of adherent monolayer cells in culture.
Chang, YC; Nalbant, P; Birkenfeld, J; Chang, ZF; Bokoch, GM. +2 more
core +1 more source
Fine mapping of posttranslational modifications of the linker histone H1 from Drosophila melanogaster. [PDF]
, 2008 The linker histone H1 binds to the DNA in between adjacent nucleosomes and contributes to chromatin organization and transcriptional control. It is known that H1 carries diverse posttranslational modifications (PTMs), including phosphorylation, lysine ...
Villar-Garea, Ana +3 more
core +2 more sources
Involvement of GEF-H1 in EC inflammatory activation induced by chronic 18% CS.
, 2016 Cells were transfected with GEF-H1-specific or non-specific siRNA, followed by 18% CS for 48 or 72 hours. (A) Effect of GEF-H1 knockdown on CS-induced ICAM1 expression was analyzed in static and stretched cells.
Anna A. Birukova (333901) +4 more
core +1 more source
, 2012 The interstitial chromosome (chr.) 1q21-q22 region is frequently amplified in human cancers, where it has been reported to carry prognostic significance for patients. We attempted to delineate chr.
Ibis KC Cheng +15 more
core +1 more source
Focal adhesions are controlled by microtubules through local contractility regulation
The EMBO JournalMicrotubules regulate cell polarity and migration via local activation of focal adhesion turnover, but the mechanism of this process is insufficiently understood.
Julien Aureille +9 more
doaj +1 more source