Results 101 to 110 of about 136,869 (147)

PGLYRP1-mediated intracellular peptidoglycan detection promotes intestinal mucosal protection

Nature Communications
Peptidoglycan recognition proteins (PGLYRPs) are implicated in the control of the intestinal microbiota; however, molecular requirements for peptidoglycan (PGN) binding and receptor signaling mechanisms remain poorly understood. Here we show that PGLYRP1
Shuyuan Chen, Rachel Putnik, Xi Li, Alka Diwaker, Marina Vasconcelos, Shuzhen Liu, Sudershan Gondi, Junhui Zhou, Lei Guo, Lin Xu, Sebastian Temme, Klare Bersch, Stephen Hyland, Jianyi Yin, Ezra Burstein, Brian J. Bahnson, Jeffrey C. Gildersleeve, Catherine Leimkuhler Grimes, Hans-Christian Reinecker   +18 more
doaj   +1 more source

Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1. [PDF]

Small GTPases, 2021
Joo E, Olson MF.
europepmc   +1 more source

The Regulatory Subunit PPP2R2A of PP2A Enhances Th1 and Th17 Differentiation through Activation of the GEF-H1/RhoA/ROCK Signaling Pathway. [PDF]

J Immunol, 2021
Pan W, Nagpal K, Suárez-Fueyo A, Ferretti A, Yoshida N, Tsokos MG, Tsokos GC.   +6 more
europepmc   +1 more source

The Role of GEF-H1 in the Regulation of the Hippo Pathway [PDF]

Microtubules are large and dynamic structures that regulate intracellular signaling, acting as scaffolds for various kinases, phosphatases, and adaptor proteins.
Cowen, Justin Gabriel
core   +1 more source

Mechanism of Gzma-Mediated GEF-H1 Activation in Intestinal Epithelial Cells Leading to Intestinal Barrier Dysfunction in Sepsis 2254641

Introduction This study investigates how Granzyme A (GZMA) induces intestinal barrier dysfunction in sepsis, specifically by activating the GEF-H1—RhoA signaling axis.
Huan Yang, Haiyang Jiang, Chujun Ni, Liting Deng, Zexing Lin, Runnan Wang, Yun Zhao   +6 more
core   +1 more source

Paclitaxel induces NM2-dependent cellular contraction through GEF-H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells. [PDF]

Mol Oncol
Asensio-Juárez G, Pérez-Díaz R, Ramos-Solano H, Garrido-Casado M, Talayero VC, Vicente-Manzanares M.   +5 more
europepmc   +1 more source

Regulation of Microtubule Stability in Pulmonary Microvascular Endothelial Cells in Rats with Severe Acute Pancreatitis: Qingyi Decoction is a Potential CDK5 Inhibitor

Journal of Inflammation Research
Yinan Cao,1– 3,* Fan Li,1– 3,* Zhenxuan Sun,1– 3 Jin Liu,1– 3 Jie Liu,1– 3 Qi Yang,1– 3 Peng Ge,1– 3 Yalan Luo,1– 3 Hailong Chen1– 3 1Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning ...
Cao Y, Li F, Sun Z, Liu J, Liu J, Yang Q, Ge P, Luo Y, Chen H   +8 more
doaj  

OptoTAT reveals microtubule acetylation as a rapid trigger for GEF-H1-mediated cell migration. [PDF]

J Cell Biol
Deb Roy A, Gonzalez CS, Stanislauskas M, Shahid F, Yadav E, Rezek J, Inoue T.   +6 more
europepmc   +1 more source

Phosphorylated cingulin localises GEF-H1 at tight junctions to protect vascular barriers in blood endothelial cells.

J Cell Sci, 2021
Holzner S, Bromberger S, Wenzina J, Neumüller K, Holper TM, Petzelbauer P, Bauer W, Weber B, Schossleitner K.   +8 more
europepmc   +1 more source

BNIP-2 retards breast cancer cell migration by coupling microtubule-mediated GEF-H1 and RhoA activation. [PDF]

Sci Adv, 2020
Pan M, Chew TW, Wong DCP, Xiao J, Ong HT, Chin JFL, Low BC.   +6 more
europepmc   +1 more source