Stiffness-activated GEF-H1 expression exacerbates LPS-induced lung inflammation. [PDF]
PLoS ONE, 2014 Acute lung injury (ALI) is accompanied by decreased lung compliance. However, a role of tissue mechanics in modulation of inflammation remains unclear.
Isa Mambetsariev +6 more
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The Microtubule-Associated Innate Immune Sensor GEF-H1 Does Not Influence Mouse Norovirus Replication in Murine Macrophages [PDF]
Viruses, 2019 Norovirus is an acute infection of the gastrointestinal tract causing rapid induction of vomiting and diarrhoea. The infection is sensed and controlled by the innate immune system, particularly by the RNA helicase MDA-5 and type I and III interferons ...
Svenja Fritzlar +2 more
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Analysis of the spatio-temporal dynamics of a Rho-GEF-H1-myosin activator-inhibitor reaction-diffusion system [PDF]
Royal Society Open ScienceThis study presents a detailed mathematical analysis of the spatio-temporal dynamics of the RhoA-GEF-H1-myosin signalling network, modelled as a coupled system of reaction-diffusion equations.
Kudzanayi Zebedia Mapfumo +4 more
doaj +3 more sources
GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors. [PDF]
PLoS Pathogens, 2008 Shigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune responses are critical for rapid
Atsuko Fukazawa +6 more
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Decoupling actin assembly from microtubule disassembly by TBC1D3C-mediated direct GEF-H1 activation [PDF]
Life Science AllianceOur findings reveal a novel mechanism whereby actin filament assembly is decoupled from microtubule disassembly, providing insights into the intricate regulation of the cytoskeleton.
Yi Luan +5 more
doaj +2 more sources
Bone resorption by osteoclasts involves fine tuning of RHOA activity by its microtubule-associated exchange factor GEF-H1 [PDF]
Frontiers in PhysiologyBone health is controlled by the balance between bone formation by osteoblasts and degradation by osteoclasts. A disequilibrium in favor of bone resorption leads to osteolytic diseases characterized by decreased bone density.
Anne Morel +3 more
doaj +2 more sources
ZO-1 Regulates Hippo-Independent YAP Activity and Cell Proliferation via a GEF-H1- and TBK1-Regulated Signalling Network [PDF]
CellsTight junctions are a barrier-forming cell–cell adhesion complex and have been proposed to regulate cell proliferation. However, the underlying mechanisms are not well understood.
Alexis J. Haas +4 more
doaj +2 more sources
A novel mechanism of FTO modulating the progression of endometriosis through mediating the m6A methylation of GEF-H1 in a YTHDF1-dependent manner [PDF]
Molecular MedicineBackground Endometriosis (EMs) is a condition characterized by the growth of endometrial tissue outside the uterine cavity. Although this condition is benign, it has cancer-like features.
Xin-Yu Ding +13 more
doaj +2 more sources
CD20 tails interact with the 14-3-3/GEF-H1 complex and microtubule network upon PKCδ phosphorylation [PDF]
The EMBO JournalCD20 is a four-helix transmembrane protein specifically expressed in B-cells that serves as a prominent target of therapeutic anti-CD20 antibodies. It is localized in a membrane nanocluster harboring the B-cell antigen receptor of IgD class (IgD-BCR ...
Kathrin Kläsener +12 more
doaj +2 more sources
S-1-propenylcysteine improves TNF-α-induced vascular endothelial barrier dysfunction by suppressing the GEF-H1/RhoA/Rac pathway [PDF]
Cell Communication and Signaling, 2021 Background Vascular endothelial barrier function is maintained by cell-to-cell junctional proteins and contributes to vascular homeostasis. Various risk factors such as inflammation disrupt barrier function through down-regulation of these proteins and ...
Kayo Kunimura +3 more
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