Results 31 to 40 of about 36,093 (252)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

In vitro and in vivo antitumor effect of gefitinib nanoparticles on human lung cancer

Drug Delivery, 2017
Gefitinib (GEF) is the first epidermal growth factor receptor (EGFR)-targeting agent launched as an anticancer drug. It is an accepted opinion that modifying GEF strong hydrophobicity and poor bioavailability would not only enhance its antitumor effects,
Xiao Ling Ni, Long Xia Chen, Heng Zhang, Bo Yang, Shan Xu, Min Wu, Jing Liu, Ling Lin Yang, Yue Chen, Shao Zhi Fu, Jing Bo Wu   +10 more
doaj   +1 more source

Surgical Removal of Residual Tumor Masses in Patients Undergoing Targeted Therapy for EGFR-Mutated Locally Advanced or Metastatic Lung Cancer. [PDF]

Int J Cancer
Non‐small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations often exhibit significant tumor reduction following tyrosine kinase inhibitor (TKI) therapy. Residual tumors frequently remain, however, leading to drug resistance and disease progression.
Moiseenko F, Stroyakovskiy D, Levchenko E, Fedyanin M, Gabina A, Oganesian A, Belukhin S, Stepanova M, Stepanova E, Artemyeva E, Myslik A, Volkov N, Bogdanov A, Shuginova T, Kryukov K, Kheinshtein V, Allakhverdiev A, Zaberegniy I, Akhmadiyarova Y, Popov M, Danilova A, Sehniaidze D, Savelov N, Levchenko N, Slugin E, Lopushanskaya O, Kuligina E, Aleksakhina S, Iyevleva A, Ivantsov A, Moiseyenko V, Imyanitov E.   +31 more
europepmc   +2 more sources

Franquia: o pitch que todo anjo pediu a Deus | Adm. Bianca Zeitoun Oglouyan | Blog GEF

, 2018
Artigo técnico profissional realizado pela Membro do GEF Adm.
GEF Grupo de Excelência em Franquias | CRA-SP (5844560)
core   +1 more source

Estratégia do Programa de Cabo Verde (2010-2014) [PDF]

, 2010
O Programa das Pequenas Subvenções do Fundo Mundial do Ambiente às ONGs (GEF SGP) é um programa a nível mundial implementado pelo PNUD e executado administrativamente pelos Escritórios das Nações Unidas para Execução de Projectos, a UNOPS.
PNUD, GEF
core  

Membros do Grupo de Excelência em Franquias - GEF

, 2018
Míni currículo dos membros GEF-2018Grupo de Excelência em Franquia no Centro de Conhecimento Conselho Regional de Administração de São Paulo - CRASP.
GEF Grupo de Excelência em Franquias | CRA-SP (5844560)
core   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Endothelial RhoGEF Trio is involved in angiogenesis

Vascular Biology
Endothelial cells lining the vessel wall are instrumental in angiogenesis. They initiate this process and remodel their actin cytoskeleton to facilitate proliferation and migration from pre-existing vessels.
Jeffrey Kroon, Ilse Timmerman, Ilkka Paatero, Mark Hoogenboezem, Serge A van de Pavert, Ester M Weijers, Pieter Koolwijk, Heinz-Georg Belting, Jaap D van Buul   +8 more
doaj   +1 more source

Corporate Social Practices and Firm Financial Performance: Empirical Evidence from France

International Journal of Financial Studies, 2021
The present work aimed to examine the association between Corporate Social performance (CSP) and corporate financial performance (CFP) taking into account corporate social irresponsibility.
Sonia Boukattaya, Abdelwahed Omri
doaj   +1 more source

A Case of Extended Spectrum GEFS+ [PDF]

Epilepsia, 2005
Summary:  A 10‐year‐old boy developed febrile convulsions at age 2 years, and multiple types of nonfebrile generalized seizures over the ensuing months and years. Gestation, birth, and early development were normal, as were initial EEG and brain imaging studies.
Arthur C, Grant, Blanca, Vazquez
openaire   +2 more sources