Results 31 to 40 of about 16,607 (189)
, 2008 International Workshop on Genetic and Evolving Fuzzy Systems, GEFS (3. 2008, Witten-Bommerholz)This work has been supported by the Spanish Ministry of Education and Science, under grants TIN2005-08036-C05-05 and TIN2006 ...
Quirin, Arnaud +5 more
core +1 more source
Temporal lobe epilepsy and GEFS(+) phenotypes associated with SCN1B mutations
, 2007 SCN1B, the gene encoding the sodium channel ß 1 subunit, was the first gene identified for generalized epilepsy with febrile seizures plus (GEFS+). Only three families have been published with SCN1B mutations.
Mulley, J. +34 more
core +1 more source
Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif
Nature Communications, 2017 Nonreceptor guanine-nucleotide exchange factors (GEFs) are emerging as important regulators of heterotrimeric G proteins. Here, the authors present structural and mechanistic insights into how a class of nonreceptor GEFs containing the Ga-Binding and ...
Alain Ibáñez de Opakua +14 more
doaj +1 more source
Novel Locus for Generalized Epilepsy with Febrile Seizures Plus
Pediatric Neurology Briefs, 2008 Linkage analysis was conducted in 5 French families with generalized epilepsy with febrile seizures plus (GEFS+), with at least 7 affected members with autosomal dominant transmission, in an attempt to localize a new gene for GEFS+, at Hospitalier Pitie ...
J Gordon Millichap
doaj +1 more source
Evaluation of candidate genes from orphan FEB and GEFS+ loci by analysis of human brain gene expression atlases. [PDF]
PLoS ONE, 2011 Febrile seizures, or febrile convulsions (FEB), represent the most common form of childhood seizures and are believed to be influenced by variations in several susceptibility genes. Most of the associated loci, however, remain 'orphan', i.e.
Rosario M Piro +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
New roles of Rac-GEFs in Neutrophils and in Glucose Homeostasis [PDF]
, 2022 Rac-GEFs (guanine-nucleotide exchange factors) are proteins that activate Rac GTPases, thereby enabling Rac-dependent cytoskeletal dynamics and cellular processes such as adhesion and migration.
core +2 more sources
Frontiers in Cell and Developmental Biology, 2023 In this article, we provide detailed protocols on using optogenetic dimerizers to acutely perturb activities of guanine nucleotide exchange factors (GEFs) specific to Ras, Rac or Rho small GTPases of the migratory networks in various mammalian and amoeba
Dhiman Sankar Pal +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Ten-Meter Wind Speed Forecast Correction in Southwest China Based on U-Net Neural Network
Atmosphere, 2023 Accurate forecasting of wind speed holds significant importance for the economic and social development of humanity. However, existing numerical weather predictions have certain inaccuracies due to various reasons.
Tao Xiang +7 more
doaj +1 more source