Results 11 to 20 of about 16,607 (189)

Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking [PDF]

BMC Biology, 2020
Background Lymphocytes circulate between peripheral lymphoid tissues via blood and lymphatic systems, and chemokine-induced migration is important in trafficking lymphocytes to distant sites.
Sayaka Ishihara, Tsuyoshi Sato, Guangwei Du, Daniele Guardavaccaro, Akihiko Nakajima, Satoshi Sawai, Tohru Kataoka, Koko Katagiri   +7 more
doaj   +2 more sources

Vagus nerve stimulation for generalized epilepsy with febrile seizures plus (GEFS+) accompanying seizures with impaired consciousness

Epilepsy and Behavior Case Reports, 2017
Generalized epilepsy with febrile seizures plus (GEFS+) is characterized by childhood-onset epilepsy syndrome. It involves febrile seizures and a variety of afebrile epileptic seizure types within the same pedigree with autosomal-dominant inheritance ...
Ryosuke Hanaya, Fajar H Niantiarno, Yumi Kashida, Hiroshi Hosoyama, Shinsuke Maruyama, Sei Sugata, Toshiaki Otsubo, Kazumi Tanaka, Atsushi Ishii, Shinichi Hirose, Kazunori Arita   +10 more
doaj   +2 more sources

Structural Insights into the Regulation Mechanism of Small GTPases by GEFs

Molecules, 2019
Small GTPases are key regulators of cellular events, and their dysfunction causes many types of cancer. They serve as molecular switches by cycling between inactive guanosine diphosphate (GDP)-bound and active guanosine triphosphate (GTP)-bound states ...
Sachiko Toma-Fukai, Toshiyuki Shimizu
doaj   +2 more sources

SCN1A mutation spectrum in a cohort of Bulgarian patients with GEFS+ phenotype [PDF]

The Turkish Journal of Pediatrics, 2020
Background. Dravet syndrome (DS) is the most severe form of Generalized Epilepsy with Febrile Seizures plus (GEFS+) syndrome with a clear genetic component in 85% of the cases.
Valentina Peycheva, Elena Rodopska, Elena Slavkova, Iliyana Aleksandrova, Emil Simeonov, Petia Dimova, Veneta Bojinova, Vanyo Mitev, Albena Jordanova, Daniela Deneva, Dimitrina Hristova, Ivan Litvinenko, Nevyana Ivanova, Kunka Kamenarova, Margarita Panova, Iliana Pacheva, Ivan Ivanov, Maria Bojidarova, Genoveva Tacheva, Dimitar Stamatov, Radka Kaneva   +20 more
doaj   +3 more sources

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity. [PDF]

Epilepsia Open
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Seyedtaghia MR, Babanzadeh J, Scala M, Perilli L, Striano P.   +4 more
europepmc   +2 more sources

FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma

Cell Reports, 2021
Summary: Despite the undisputable role of the small GTPase Rac1 in the regulation of actin cytoskeleton reorganization, the Rac guanine-nucleotide exchange factors (Rac-GEFs) involved in Rac1-mediated motility and invasion in human lung adenocarcinoma ...
Mariana Cooke, Gabriel Kreider-Letterman, Martin J. Baker, Suli Zhang, Neil T. Sullivan, Evgeniy Eruslanov, Martin C. Abba, Silvia M. Goicoechea, Rafael García-Mata, Marcelo G. Kazanietz   +9 more
doaj   +1 more source

VAV Proteins as Double Agents in Cancer: Oncogenes with Tumor Suppressor Roles

Biology, 2021
Guanosine nucleotide exchange factors (GEFs) are responsible for catalyzing the transition of small GTPases from the inactive (GDP-bound) to the active (GTP-bound) states. RHO GEFs, including VAV proteins, play essential signaling roles in a wide variety
Myriam Cuadrado, Javier Robles-Valero
doaj   +1 more source

GENETIC EPILEPSY WITH FEBRILE SEIZURES PLUS CAUSED BY SCN1A GENE MUTATION: A FAMILY REPORT AND LITERATURE REVIEW [PDF]

精准医学杂志, 2023
Objective To summarize the clinical features and treatment of genetic epilepsy with febrile seizures plus (GEFS+) caused by SCN1A gene mutations, to improve the understanding of SCN1A gene mutations, and to provide a basis for the clinical diagnosis and ...
XU Kai, HUANG Shuo, ZHU Haifang, SUN Yanping
doaj   +1 more source

Development and evaluation of the Aerosol Forecast Member in the National Center for Environment Prediction (NCEP)'s Global Ensemble Forecast System (GEFS-Aerosols v1) [PDF]

Geoscientific Model Development, 2022
The National Oceanic and Atmospheric Administration (NOAA)'s National Weather Service (NWS) is on its way to deploying various operational prediction applications using the Unified Forecast System (https://ufscommunity.org/, last access: 18 June 2022), a
L. Zhang, L. Zhang, R. Montuoro, R. Montuoro, R. Montuoro, S. A. McKeen, S. A. McKeen, B. Baker, B. Baker, P. S. Bhattacharjee, G. A. Grell, J. Henderson, L. Pan, G. J. Frost, J. McQueen, R. Saylor, H. Li, H. Li, R. Ahmadov, R. Ahmadov, J. Wang, I. Stajner, S. Kondragunta, X. Zhang, F. Li   +24 more
doaj   +1 more source

Analysis of the GEFS-Aerosols annual budget to better understand aerosol predictions simulated in the model [PDF]

Geoscientific Model Development
In September 2020, a global aerosol forecasting model was implemented as an ensemble member of the National Oceanic and Atmospheric Administration (NOAA) National Centers for Environmental Prediction (NCEP) Global Ensemble Forecasting System (GEFS) v12.0.
L. Pan, P. S. Bhattacharjee, L. Zhang, L. Zhang, R. Montuoro, B. Baker, J. McQueen, G. A. Grell, S. A. McKeen, S. A. McKeen, S. A. McKeen, S. Kondragunta, X. Zhang, G. J. Frost, F. Yang, I. Stajner   +15 more
doaj   +1 more source