Results 41 to 50 of about 572,418 (279)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Quantification of growth kinetics and adherence of oxide scales formed on Ni-based superalloys at high temperature [PDF]

, 2010
Cyclic and isothermal oxidation behaviors of first and fourth-generation superalloys AM1 and MCNG were investigated to evaluate the ability of the scratch test to quantify the adhesion of multi-layered oxide scales. Effects of sulfur content and of scale
Fedorova, Elena, Monceau, Daniel, Oquab, Djar   +2 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Ensino de pensamento computacional para alunos do ensino básico usando Computação Desplugada e Scratch

Em Extensão, 2022
A tecnologia está cada vez mais presente no cotidiano das pessoas, portanto, torna- se um importante recurso no processo de ensino e aprendizagem, com possibilidade de adoção não apenas em contextos específicos de cunho tecnológico, mas também em ...
Amanda Karollyne Monteiro Rodrigues, Ana Paula Mundim Silva, Murillo Guimarães Carneiro   +2 more
doaj   +1 more source

Agent-based computational modeling of wounded epithelial cell monolayers [PDF]

, 2004
Computational modeling of biological systems, or ‘in silico biology’ is an emerging tool for understanding structure and order in biological tissues. Computational models of the behavior of epithelial cells in monolayer cell culture have been developed ...
Hill, G., Smallwood, R.H., Southgate, J., Walker, D.C., Wood, S.M.   +4 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Educación a distancia. Reto de la superación a través del curso Algoritmización con Scratch

Serie Científica de la Universidad de las Ciencias Informáticas, 2021
Los profesionales de informática y ramas afines reciben actividades de superación a través de la modalidad a distancia. La educación a distancia con el uso de las Tecnologías de la Información y las Comunicaciones (TIC), es una necesidad para la ...
Yor Alex Remond Recio, Rosa María Figueredo Rodríguez   +1 more
doaj  

Gamification with Scratch or App Inventor in Higher Education: A Systematic Review

Future Internet, 2022
Programming skills should be taught and developed; Scratch and App Inventor are two tools that can contribute significantly to developing this competence in university students.
David Pérez-Jorge, María Carmen Martínez-Murciano   +1 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Optimizing intrauterine insemination: A systematic review and meta‐analysis of the effectiveness and safety of clinical treatment add‐ons

Acta Obstetricia et Gynecologica Scandinavica
Introduction Intrauterine insemination (IUI) is one of the most widespread fertility treatments. However, IUI protocols vary significantly amongst fertility clinics. Various add‐on interventions have been proposed to boost success rates. These are mostly
Elpiniki Chronopoulou, Andrea Gaetano‐Gil, Sadaf Shaikh, Claudia Raperport, Bassel H. Al Wattar, Gabriel Ruiz‐Calvo, Javier Zamora, Priya Bhide   +7 more
doaj   +1 more source