Results 51 to 60 of about 572,418 (279)

Understanding Prospective Teachers’ Task Design Considerations through the Lens of the Theory of Didactical Situations

open access: yesMathematics, 2022
Task design, in general, and task design in a technological environment, is attracting the attention of educational researchers. The present research investigates task design of prospective teachers in the Scratch programming environment.
Wajeeh Daher   +2 more
doaj   +1 more source

Experimental and numerical study on scratching test [PDF]

open access: yes, 2013
This paper presents recent investigation of the material removal mechanism in single grit grinding test. Single grit scratches were generated experimentally by using CBN grit on En24T steel and compared with numerical simulation by using finite element ...
Chen, Xun, Öpöz, Tahsin
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

When Developing a Career Path, What are the Key Elements to Include? [PDF]

open access: yes, 2013
Question: When developing a career path from scratch, what are the key elements to include in the design process and what factors lead to a successful ...
Cao, Jing, Thomas, Desiree
core   +1 more source

Learning Language Games through Interaction

open access: yes, 2016
We introduce a new language learning setting relevant to building adaptive natural language interfaces. It is inspired by Wittgenstein's language games: a human wishes to accomplish some task (e.g., achieving a certain configuration of blocks), but can ...
Liang, Percy   +2 more
core   +1 more source

Creating R Packages: A Tutorial [PDF]

open access: yes, 2008
This tutorial gives a practical introduction to creating R packages. We discuss how object oriented programming and S formulas can be used to give R code the usual look and feel, how to start a package from a collection of R functions, and how to test ...
Brito, Paula, Leisch, Friedrich
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Programlama Öğretim Sürecinde Üstün Yetenekli İlkokul Öğrencilerinin Görüşlerinin İncelenmesi

open access: yesAnkara Üniversitesi Eğitim Bilimleri Fakültesi Dergisi, 2019
Programlama etkinliklerinin erken yaşta deneyimlenmesi gün geçtikçe önem kazanan bir konudur. Bu çalışmada ilkokul 2., 3. ve 4. sınıfta öğrenim gören 26 üstün yetenekli öğrenci ile Scratch destekli programlama öğretimine yönelik 15 haftalık bir uygulama ...
Hatice Yıldız Durak, Tolga Güyer
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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