Results 61 to 70 of about 583,399 (327)
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Unsupervised Transfer Learning for Spoken Language Understanding in Intelligent Agents
, 2018 User interaction with voice-powered agents generates large amounts of unlabeled utterances. In this paper, we explore techniques to efficiently transfer the knowledge from these unlabeled utterances to improve model performance on Spoken Language ...
Goyal, Anuj +2 more
core +1 more source
FEBS Open Bio, EarlyView.Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar +3 more
wiley +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
A nanometric cushion for enhancing scratch and wear resistance of hard films
Beilstein Journal of Nanotechnology, 2014 Scratch resistance and friction are core properties which define the tribological characteristics of materials. Attempts to optimize these quantities at solid surfaces are the subject of intense technological interest.
Katya Gotlib-Vainshtein +4 more
doaj +1 more source
A Dialogue Between Computational Thinking and Interdisciplinarity using Scratch Software
Uni-pluriversidad, 2020 In this paper, the purpose is to discuss results of a continuing education action with tea-chers, linked to the university extension project Computational Thinking and Interdisciplina-rity in the classroom, developed within the Postgraduate Program in ...
Maria Teresa Zampieri +1 more
doaj +1 more source
Magnetically actuated tuning method for Gunn oscillators [PDF]
, 1972 A tunable microwave generator based on the Gunn effect is disclosed. The generator includes a semiconductor material which exhibits the Gunn effect when current flows between anode and cathode end contacts.
Sacks, B. H.
core +1 more source
Digging down or scratching the surface: how patients use metaphors to describe their experiences of psychotherapy [PDF]
, 2021 Anders Malkomsen +6 more
openalex +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan +6 more
wiley +1 more source