Results 191 to 200 of about 2,627,927 (334)

The association of screen time and the risk of sleep outcomes: a systematic review and meta-analysis. [PDF]

open access: yesFront Psychiatry
He X   +9 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Screen Time and Musculoskeletal Pain in Dental Students

open access: yesPesquisa Brasileira em Odontopediatria e Clínica Integrada
Objective: To investigate the association between screen time and musculoskeletal pain in dentistry students at a Brazilian public university.
Manuella Vasconcelos Tavares Carvalho   +6 more
doaj  

Correction: The relationship between screen time, screen content for children aged 1-3, and the risk of ADHD in preschools. [PDF]

open access: yesPLoS One
Wu JB   +11 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Sleep Duration and Screen Time in Young Children with Mild Language Delays. [PDF]

open access: yesChildren (Basel)
Malik S   +5 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

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