Results 141 to 150 of about 29,746,039 (283)
Brain Pathology, EarlyView.Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová +19 more
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British Journal of Pharmacology, EarlyView.Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu +9 more
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BMC Endocrine DisordersIntroduction Stromal cell-derived factor-1 (SDF-1) is a newly discovered small molecule adipocytokine, and research has shown that it is closely related to the occurrence and development of obesity.
Yuesheng Liu +5 more
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British Journal of Pharmacology, EarlyView.Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka +3 more
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血清SDF-1联合CXCL5及CEA联合检测用于乳腺癌诊断的敏感度与特异性分析
Zhongguo shiyan zhenduanxue, 2018 目的探究并分析血清SDF-1(基质细胞衍生因子-1)联合CXCL5(外周血趋化因子-5)及CEA(癌胚抗原)联合检测用于乳腺癌诊断的敏感度与特异性。方法选取2015年6月-2016年6月收治的50例乳腺癌患者,50例乳腺良性肿瘤患者及50名正常志愿者,分别作为乳腺癌组、乳腺良性肿瘤组及对照组。测定各组患者血清SDF-1、CXCL5及CEA浓度,采用血清SDF-1、CXCL5、CEA及SDF-1+CXCL5作为诊断指标对所有受试者进行诊断,比较上述诊断方法的准确性(包括敏感性、特异性及一致性 ...
安雪青, 吕健东, 苏锋, 赵建勋
doaj
Cancer Science, EarlyView.This study identified LAMC2+ epithelial cells through single‐cell sequencing and found that high expression of LAMC2 is associated with the malignant progression of bladder cancer. HdWGCNA and transcriptome sequencing revealed the SerpinB3/STAT3/CD44 axis. Diosmetin was selected as a potential LAMC2 inhibitor.
Yutong Chen +17 more
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
SDFs from Unoriented Point Clouds using Neural Variational Heat Distances
Computer Graphics Forum, EarlyView.We propose a novel variational approach for computing neural Signed Distance Fields (SDF) from unoriented point clouds. We first compute a small time step of heat flow (middle) and then use its gradient directions to solve for a neural SDF (right). Abstract We propose a novel variational approach for computing neural Signed Distance Fields (SDF) from ...
Samuel Weidemaier +5 more
wiley +1 more source
A Real‐Time Multi‐Scale Neural Representation for Complex Surface Reflectance
Computer Graphics Forum, EarlyView.Abstract Recent machine learning methods have significantly advanced the state of the art in the classic problem of representing surface appearance over angle, space, and scale. The models tend, however, to be relatively heavy compared to traditional fixed‐function representations, making real‐time application challenging.
Heikki Timonen +2 more
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Computer Graphics Forum, EarlyView.Abstract While semi‐analytical boundary handling techniques have proven effective for modeling particle‐based fluid‐solid interactions, they can become unstable when applied to mesh boundaries undergoing dynamic motion or featuring complex, sharp geometries.
Junyuan Liu +5 more
wiley +1 more source