Results 291 to 300 of about 27,322,199 (337)
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Serum albumin strongly influences SDF-1 dependent migration
International Journal of Hematology, 2009Stem cell migration is largely regulated by the chemokine SDF-1 and its receptor CXCR4. In the present study, we analyzed the effect of protein on SDF-1 dependent chemotaxis using CXCR4 expressing primary CD34+ hematopoietic progenitor cells for transwell migration assays.
Martin F, Ryser +4 more
openaire +2 more sources
ACS Applied Materials and Interfaces, 2018
Stem cells are well-known for their great capacity for tissue regeneration. This provides a promising source for cell-based therapies in treating various bone degenerative disorders. However, the major hurdles for their application in transplantation are
Qingchang Chen +6 more
semanticscholar +1 more source
Stem cells are well-known for their great capacity for tissue regeneration. This provides a promising source for cell-based therapies in treating various bone degenerative disorders. However, the major hurdles for their application in transplantation are
Qingchang Chen +6 more
semanticscholar +1 more source
Targeting SDF-1 in multiple myeloma tumor microenvironment
Cancer Letters, 2016Multiple myeloma (MM) is a type of B-cell malignancy that remains incurable to date. The bone marrow (BM) microenvironment plays a crucial role in MM progression. The chemokine SDF-1 (CXCL12) is an important actor of the BM microenvironment that has the ability to regulate numerous processes related to its malignant transformation during MM development.
Juliette M C, Bouyssou +2 more
openaire +2 more sources
International journal of pharmaceutics, 2018
Ensuring an adequate angiogenic response during wound healing is a prevailing clinical challenge in biomaterials science. To address this, we aimed to develop a pro‐angiogenic gene‐activated scaffold (GAS) that could activate MSCs to produce paracrine ...
A. L. Laiva +3 more
semanticscholar +1 more source
Ensuring an adequate angiogenic response during wound healing is a prevailing clinical challenge in biomaterials science. To address this, we aimed to develop a pro‐angiogenic gene‐activated scaffold (GAS) that could activate MSCs to produce paracrine ...
A. L. Laiva +3 more
semanticscholar +1 more source
SDF-1: the repulsive chemokine
Immunology Today, 20001 Mark C. Poznansky et al. (2000) Active movement of T cells away from a chemokine. Nat. Med. 6, 543–548Chemokines set up concentration (or chemotactic) gradients in tissue, which influence target cells to migrate towards their source – ‘up’ concentration gradients.
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CXCR4–SDF-1 Signalling, Locomotion, Chemotaxis and Adhesion
Journal of Molecular Histology, 2004Chemokines, small pro-inflammatory chemoattractant cytokines, that bind to specific G-protein-coupled seven-span transmembrane receptors present on plasma membranes of target cells are the major regulators of cell trafficking. In addition some chemokines have been reported to modulate cell survival and growth.
Magda, Kucia +8 more
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Increase in Circulating SDF‐1 after Treatment with Sulfated Glycans
Annals of the New York Academy of Sciences, 2001Abstract: SDF‐1 is a potent chemoattractant for mature white blood cells and hemopoietic stem/progenitor cells (HPCs). An important role for this chemo‐kine in mobilization has been postulated, but in vivo studies directly addressing its effects are lacking.
E A, Sweeney, T, Papayannopoulou
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The significance of the SDF-1/CXCR4 signaling pathway in the normal development
Molecular Biology Reports, 2022Farzad Sadri, Z. Rezaei, M. Fereidouni
semanticscholar +1 more source
Blood, 2012
Abstract Abstract 2441 SDF-1 (CXCL12) is a chemokine vastly secreted from bone marrow-stromal cells (BM-SC), and plays a pivotal role for multiple biological events in a variety of cells. Hematopoietic stem cells express its receptor CXCR4 at high levels and the SDF-1/CXCR4 system is profoundly implicated in their homing ...
Norie Ando +6 more
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Abstract Abstract 2441 SDF-1 (CXCL12) is a chemokine vastly secreted from bone marrow-stromal cells (BM-SC), and plays a pivotal role for multiple biological events in a variety of cells. Hematopoietic stem cells express its receptor CXCR4 at high levels and the SDF-1/CXCR4 system is profoundly implicated in their homing ...
Norie Ando +6 more
openaire +1 more source
SDF-1 stimulates neurite growth on inhibitory CNS myelin
Molecular and Cellular Neuroscience, 2009Impaired axonal regeneration is a common observation after central nervous system (CNS) injury. The stromal cell-derived factor-1, SDF-1/CXCL12, has previously been shown to promote axonal growth in the presence of potent chemorepellent molecules known to be important in nervous system development.
Jessica, Opatz +7 more
openaire +2 more sources