Results 51 to 60 of about 27,322,199 (337)

SDF-1/CXCR4 axis facilitates myeloid-derived suppressor cells accumulation in osteosarcoma microenvironment and blunts the response to anti-PD-1 therapy.

International Immunopharmacology, 2019
Immune checkpoint inhibitors, such as anti-PD-1/PD-L1, are a novel class of inhibitors that function as a tumor suppressing factor via modulation of immune cell-tumor cell interaction.
Kuo Jiang, Jia Li, Jitao Zhang, Lei Wang, Qianfeng Zhang, Junli Ge, Yunshan Guo, Biao Wang, Yi Huang, Tuanmin Yang, D. Hao, L. Shan   +11 more
semanticscholar   +1 more source

Phosphoric Acid Etch Partially Restores the Initial Bond Strength of Composite to Silver Diamine Fluoride–Treated Enamel Using Universal Adhesives

Dentistry Journal, 2023
Background: Restoring bonding composite to silver diamine fluoride (SDF)-treated enamel is challenging. This study investigates if phosphoric acid etch restores composite bond strength to SDF-treated enamel using universal adhesives. Methods: Twenty-four
Zaher Jabbour, Mijoo Kim, Marc Hayashi, Reuben Kim   +3 more
doaj   +1 more source

Role of the HIF-1α/SDF-1/CXCR4 signaling axis in accelerated fracture healing after craniocerebral injury

Molecular Medicine Reports, 2020
The hypoxic state of the brain tissue surrounding craniocerebral injury induces an increase in the secretion of HIF-1α during the healing process. HIF-1α can promote mesenchymal stem cell (MSC) migration to ischemic and hypoxic sites by regulating the ...
Yonghua Xue, Zhikun Li, Yi Wang, Xiaodong Zhu, Ruixi Hu, Wei Xu   +5 more
semanticscholar   +1 more source

Src as the link between inflammation and cancer. [PDF]

, 2013
Although a causal link between chronic inflammation and cancer has been established, the exact molecular mechanism linking inflammation to cancer remains largely unknown.
Andrzej ePtasznik, Hung ePham, Sandy eLiu, Stephen J Pandol, Stephen J Pandol   +4 more
core   +2 more sources

CXC chemokine ligand 12/Stromal cell-derived factor-1 regulates cell adhesion in human colon cancer cells by induction of intercellular adhesion molecule-1

Journal of Biomedical Science, 2012
Background The CXC chemokine ligand 12 (CXCL12)/stromal cell-derived factor-1 (SDF-1) and CXC receptor 4 (CXCR4) axis is involved in human colorectal cancer (CRC) carcinogenesis and can promote the progression of CRC.
Tung Shui-Yi, Chang Shun-Fu, Chou Ming-Hui, Huang Wen-Shih, Hsieh Yung-Yu, Shen Chien-Heng, Kuo Hsing-Chun, Chen Cheng-Nan   +7 more
doaj   +1 more source

Cancer-associated fibroblasts promote progression and gemcitabine resistance via the SDF-1/SATB-1 pathway in pancreatic cancer

Cell Death and Disease, 2018
Cancer-associated fibroblasts (CAFs), a dominant component of the pancreatic tumor microenvironment, are mainly considered as promotors of malignant progression, but the underlying molecular mechanism remains unclear. Here, we show that SDF-1 secreted by
Lusheng Wei, Huilin Ye, Guolin Li, Yuanting Lu, Quanbo Zhou, Shangyou Zheng, Qing Lin, Yimin Liu, Zhihua Li, Rufu Chen   +9 more
semanticscholar   +1 more source

CXCR4 pos circulating progenitor cells coexpressing monocytic and endothelial markers correlating with fibrotic clinical features are present in the peripheral blood of patients affected by systemic sclerosis [PDF]

, 2008
There is still controversy regarding the role of circulating endothelial and progenitor cells (CECs/CEPs) in the pathogenesis of systemic sclerosis (SSc).
CAMPIONI, Diana, CUNEO, Antonio, Ferrari, L, FOTINIDI, Maria, LA CORTE, Renato, LANZA, Francesco, LO MONACO, Andrea, Moretti, S, TROTTA, Francesco   +8 more
core   +2 more sources

Effect of integrin α5β1 inhibition on SDF-l/CXCR4- mediated choroidal neovascularization [PDF]

International Journal of Ophthalmology, 2018
AIM: To investigate the roles of integrins in choroidal neovascularization (CNV) and their associations with the stromal cell-derived factor-1 (SDF-1)/CXCR4 axis. METHODS: CNV lesions were induced in mice using laser photocoagulation.
Yang Lyu, Wen-Qin Xu, Li-Juan Sun, Xiao-Yan Pan, Jian Zhang, Yu-Sheng Wang   +5 more
doaj   +1 more source

The Role of SDF-1/CXCR4/CXCR7 in Neuronal Regeneration after Cerebral Ischemia

Frontiers in Neuroscience, 2017
Stromal cell-derived factor-1 is a chemoattractant produced by bone marrow stromal cell lines. It is recognized as a critical factor in the immune and central nervous systems (CNSs) as well as exerting a role in cancer.
Xi Cheng, Huibin Wang, Xiuchun Zhang, Shanshan Zhao, Zhike Zhou, X. Mu, Chuansheng Zhao, Weiyu Teng   +7 more
semanticscholar   +1 more source

Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer [PDF]

, 2017
Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator ...
Borzone, Francisco Raúl, Chasseing, Norma Alejandra, Choi, Hosoon, Davies, Kevin Mauro, de Luján Calcagno, María, Feldman, Leonardo, García Rivello, Hernán, Giorello, María Belén, Howard, Scott C., Labovsky, Vivian, Martinez, Leandro Marcelo, Matas, Ayelen, Wernicke, Alejandra   +12 more
core   +2 more sources