Results 61 to 70 of about 14,136,043 (289)

(Esa tela) se la descose: la pronominalización del paciente en las impersonales reflejas del español peninsular

open access: yesBorealis: An International Journal of Hispanic Linguistics, 2013
En este trabajo investigamos la pronominalización del paciente en las oraciones conocidas como impersonales reflejas en español peninsular, desde dos puntos de vista: el tipo de paciente que se pronominaliza y el pronombre que se emplea para ello.
Carlota de Benito Moreno
doaj   +1 more source

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh   +5 more
wiley   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad   +4 more
wiley   +1 more source

Differential Object Marking in Spanish: state of the art

open access: yesBorealis: An International Journal of Hispanic Linguistics, 2013
This state of the art tries to cover as much as possible about the properties, conditions and analyses of Differential Object Marking (DOM) in Spanish.
Antonio Fábregas
doaj   +1 more source

Enzymes from fish processing waste materials and their commercial applications

open access: yes, 2013
Enzyme technology is an indispensable part of today's industrial processes and, hence, the global market for industrial enzymes continues to expand. The manufacturing of enzymes has become the cash cow of many businesses.
Kim, Se-Kwon   +3 more
core   +1 more source

Adverse events in bedaquiline‐ and pretomanid‐based regimens for drug‐resistant tuberculosis from trial, implementation and pharmacovigilance studies

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract The availability of safety data, particularly concerning adverse events (AEs) associated with the new shorter regimen for drug‐resistant tuberculosis (TB) containing a bedaquiline–pretomanid‐based regimen, is still limited. This systematic review aims to provide a comprehensive and updated analysis of AEs related to this new regimen by ...
Nisa Maria   +4 more
wiley   +1 more source

Interlayer Repulsion of Retinal Ganglion Cell Mosaics Regulates Spatial Organization of Functional Maps in the Visual Cortex

open access: yes, 2017
In higher mammals, orientation tuning of neurons is organized into a quasi-periodic pattern in the primary visual cortex. Our previous model studies suggested that the topography of cortical orientation maps may originate from moiré interference of ON ...
Paik, Se-Bum   +3 more
core   +1 more source

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert   +6 more
wiley   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar   +6 more
wiley   +1 more source

Simultaneous Determination of Ge, Se and Te in Geological Samples by Inductively Coupled Plasma-Mass Spectrometry

open access: yesYankuang ceshi, 2014
The analysis of Ge, Se and Te requires that samples be dissolved by two different acid systems of HNO3-HF-HClO4-H3PO4 and HNO3-HF-HClO4, and determined by Atomic Fluorescence Spectrometry (AFS) and Inductively Coupled Plasma-Mass Spectrometry (ICP-MS ...
CHEN Bo, LIU Hong-qing, XING Ying-xiang
doaj   +2 more sources

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