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Efficacy and Safety of Subcutaneous Efgartigimod PH20 in Adults With Primary Immune Thrombocytopenia (ADVANCE SC): A Multicenter, Randomized, Double‐Blinded, Placebo‐Controlled, Phase 3 Trial

American Journal of Hematology, EarlyView.
ABSTRACT Primary autoimmune thrombocytopenia (ITP) is characterized by thrombocytopenia, bleeding, and reduced health‐related quality of life. In the Phase 3 ADVANCE IV study, intravenous efgartigimod induced significant platelet count responses versus placebo in patients with chronic ITP. ADVANCE SC, a Phase 3, multicenter, randomized, double‐blinded,
Nichola Cooper +546 more
wiley +1 more source

La posición de se en las estructuras pluriverbales: variación y significado The placement of the clitic se in verbal compounds: Variation and meaning

Boletín de Filología, 2010
La definición de variables morfosintácticas suele basarse en la identidad de sus variantes en el nivel semántico descriptivo; no obstante, a menudo existen diferencias en los planos del discurso y la cognición. Así, las formas reflexivas del paradigma de
Miguel Ángel Aijón Oliva
doaj

Intersubjective Impersonals in Context: A Multivariate Analysis of Spanish “Uno” and “Se” in Spoken Language

Catalan Journal of Linguistics, 2020
This paper offers a multivariate analysis of the alternation between 2 Spanish constructions traditionally considered as impersonal, namely uno and se, in 3 different spoken language genres.
Barbara De Cock
doaj +1 more source

Morphological and morphometric aspects of the equine aortic valve: New insights for comparative studies in mammals

The Anatomical Record, EarlyView.
Abstract New data on the equine aortic valve obtained using advanced techniques is especially important given the greater availability of animal models for translational research. Here we characterized the morphological and morphometric aspects of the equine aortic valve from 60 healthy hearts collected at equine abattoirs.
Vitor Pires Pereira +3 more
wiley +1 more source

The role of influenza neuraminidase transmembrane domain on budding and virus morphology [PDF]

, 2014
Influenza A virus neuraminidase (NA), a type II transmembrane glycoprotein plays a role in the cleavage of sialic acids and facilitating the release of mature virions from the surface of infected cells. NA has also previously been shown to play a role in
Roddy, Scott, Edward
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Efficacy and Safety of Subcutaneous Anifrolumab in Systemic Lupus Erythematosus: A Randomized, Phase 3 Study

Arthritis &Rheumatology, EarlyView.
Objective The multinational, phase 3, double‐blind, placebo‐controlled TULIP‐SC trial evaluated the efficacy and safety of subcutaneous anifrolumab in adults who have moderate to severe systemic lupus erythematosus (SLE) activity, despite receiving standard therapy. Methods Adults with SLE received subcutaneous anifrolumab 120 mg or placebo once weekly
Susan Manzi +12 more
wiley +1 more source

Hashimoto Tiroiditli Hastalarda Bakır, Demir, Çinko, Selenyum Düzeyleri ve Cu/Se, Cu/Zn, Fe/Se, Fe/Zn Oranlarının Araştırılması

Sakarya Tıp Dergisi, 2018
Amaç: Bu çalışmanın amacı, Hashimoto tiroiditi (HT) etiyopatogenezinde selenyum (Se) demir (Fe), çinko (Zn) ve bakır (Cu) eser elementlerinin serum düzeylerindeki ve oranlarındaki değişimlerinin belirlenmesi ve bu parametreler arasındaki olası ilişkinin ...
Birsen Aydemir +7 more
doaj +1 more source

A Novel Study of the Relation Between Students Navigational Behavior on Blackboard and their Learning Performance in an Undergraduate Networking Course

, 2018
This paper provides an overview of students behavior analysis on a learning management system (LMS), Blackboard (Bb) Learn for a core data communications course of the Undergraduate IT program in the Information Sciences and Technology (IST) Department ...
Ahmadi, Pouyan, Islam, Khondkar, Yousaf, Salman +2 more
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Efficacy and Safety of Guselkumab in Participants With Active Psoriatic Arthritis After Inadequate Response to One Prior Tumor Necrosis Factor Inhibitor: Week‐24 Results of a Phase 3, Randomized, Placebo‐Controlled Study

Arthritis &Rheumatology, EarlyView.
Objective To evaluate the efficacy and safety of guselkumab, an interleukin‐23p19 subunit inhibitor, in participants with active psoriatic arthritis (PsA) and inadequate response (inadequate efficacy and/or intolerance) to one prior tumor necrosis factor (TNF) inhibitor.
Alexis Ogdie +12 more
wiley +1 more source

Application of local and non-local approaches to multiple fatigue crack initiation and propagation [PDF]

, 2003
Fatigue strength conditions presented in terms of normalized equivalent stress functionals defined on loading processes are used to unite the stages of material damage with fatigue crack initiation and multiple crack propagation under arbitrary loading ...
Mikhailov, SE, Namestnikova, IV
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