Results 71 to 80 of about 24,482,269 (284)

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Local and non-local normalised equivalent strain functionals for cyclic fatigue [PDF]

, 2004
The concept of Cyclic Normalised Equivalent Strain Functionals (CNESnFs) suitable for lowcyclic fatigue is developed in this paper. It reduces any fatigue strength and durability model to a unique form what facilitates the models comparison ...
Mikhailov, SE, Namestnikova, IV
core   +1 more source

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

British Journal of Clinical Pharmacology, EarlyView.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

Serum Levels of Zinc, Copper, Selenium and Glutathione Peroxidase in Different Groups of Colorectal Cancer Patients

Caspian Journal of Internal Medicine, 2020
Background: Colorectal cancer (CRC) is considered the fourth type of cancer that causes death in the world. Changes in levels of Zinc (Zn), Copper (Cu), and Selenium (Se) as well as low glutathione peroxidase (GPx) activity can lead to CRC and this study
Ghassan Sulaiman, Raghad Al-ansari, Abdulnasser AL-Gebori   +2 more
doaj  

(Esa tela) se la descose: la pronominalización del paciente en las impersonales reflejas del español peninsular

Borealis: An International Journal of Hispanic Linguistics, 2013
En este trabajo investigamos la pronominalización del paciente en las oraciones conocidas como impersonales reflejas en español peninsular, desde dos puntos de vista: el tipo de paciente que se pronominaliza y el pronombre que se emplea para ello.
Carlota de Benito Moreno
doaj   +1 more source

A Novel Study of the Relation Between Students Navigational Behavior on Blackboard and their Learning Performance in an Undergraduate Networking Course

, 2018
This paper provides an overview of students behavior analysis on a learning management system (LMS), Blackboard (Bb) Learn for a core data communications course of the Undergraduate IT program in the Information Sciences and Technology (IST) Department ...
Ahmadi, Pouyan, Islam, Khondkar, Yousaf, Salman   +2 more
core  

Ergonomisch gestaltetes 3-Schichtsystem mit Nachtschichtreduktion für alle Beschäftigten [PDF]

, 2017
Nacht- und Schichtarbeit stellt eine besondere Belastung und Beanspruchung dar. Gemäß arbeitswissenschaftlicher Empfehlungen sollte die Phase des Arbeitens und Ruhens gegen den biologischen Schlaf-Wach-Rhythmus möglichst kurz sein.
Jaeger, Corinna
core  

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Pharmacokinetics, safety, tolerability and fluorescence imaging of nizaracianine triflutate administered in three divided doses to healthy volunteers

British Journal of Clinical Pharmacology, EarlyView.
Aim Fluorescence‐guided surgery enhances intraoperative visualization of anatomical structures. Nizaracianine is a near‐infrared fluorescent agent that is exclusively renally cleared in animal models. It enables real‐time ureteral imaging and identification, potentially reduces risk of injury and facilitates assessment before surgical closure.
Lisanne K. A. Neijenhuis, Cedric M. W. Pesch, John V. Frangioni, Alexander L. Vahrmeijer, Jacobus Burggraaf, Naomi B. Klarenbeek   +5 more
wiley   +1 more source

Reconstrucción de precipitación invierno-primavera para el Parque Nacional Pico de Tancítaro, Michoacán

Investigaciones Geográficas, 2014
Desde la perspectiva del recurso hídrico, el Pico de Tancítaro representa una riqueza hidrológica para la re- gión y el principal elemento para su desarrollo económico.
Julián Cerano Paredes, José Villanueva Díaz, Rosalinda Cervantes Martínez, Lorenzo Vázquez Selem, Ramón Trucios Caciano, Vidal Guerra de la Cruz   +5 more
doaj