Results 111 to 120 of about 3,539,778 (300)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Inland thinning of the Amundsen Sea sector, West Antarctica [PDF]
, 2002 [1] Together with the Pine Island glacier (PIG), the Thwaites (TG) and Smith (SG) glaciers are the principal drainage systems of the Amundsen Sea (AS) sector of Western Antarctica.
Wingham, DJ, Shepherd, A, Mansley, JAD
core
Trimlines, blockfields and the vertical extent of the last ice sheet in southern Ireland [PDF]
, 2015 The research reported here was supported by UK NERC grant NER/B/S/2001/0919Trimlines separating glacially abraded lower slopes from blockfield-covered summits on Irish mountains have traditionally been interpreted as representing the upper limit of the ...
Stone, John O. +3 more
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Modeled and gridded sea ice data
, 2007 Modelling data from OMIP (Ocean model intercomparison project) _______________ 14 sea ice variables: Mask scalar points [0/1] Mask vector points [0/1] Sea ice thickness [m] Sea ice concentration [percent] Zonal sea ice velocity [m/s] Meridional sea ice ...
Fritzsch, Bernadette +3 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Barents Sea ice cover reflects Atlantic inflow [PDF]
, 2011 The recent Arctic winter sea-ice retreat is most pronounced in the Barents Sea. Using available observations of the Atlantic inflow to the Barents Sea and results from a regional ice-ocean model we assess the role of inflowing heat anomalies on sea-ice ...
Skagseth, Øystein +3 more
core
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source