Results 101 to 110 of about 554,659 (340)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Assessing the O2 budget under sea ice: An experimental and modelling approach

Elementa: Science of the Anthropocene, 2015
The objective of this study was to assess the O2 budget in the water under sea ice combining observations and modelling. Modelling was used to discriminate between physical processes, gas-specific transport (i.e., ice-atmosphere gas fluxes and gas bubble
S. Moreau, H. Kaartokallio, M. Vancoppenolle, J. Zhou, M. Kotovitch, G. S. Dieckmann, D.N. Thomas, J.-L. Tison, B. Delille   +8 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Effect of frequent winter warming events (storms) and snow on sea-ice growth – a case from the Atlantic sector of the Arctic Ocean during the N-ICE2015 campaign

Annals of Glaciology, 2020
We examine the relative effect of warming events (storms) and snow cover on thermodynamic growth of Arctic sea ice in winter. We use a 1-D snow and ice thermodynamic model to perform sensitivity experiments.
Ioanna Merkouriadi, Bin Cheng, Stephen R. Hudson, Mats A. Granskog   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Large-scale features of Pliocene climate: results from the Pliocene Model Intercomparison Project [PDF]

, 2013
Climate and environments of the mid-Pliocene warm period (3.264 to 3.025 Ma) have been extensively studied. Whilst numerical models have shed light on the nature of climate at the time, uncertainties in their predictions have not been systematically ...
Abe-Ouchi, Ayako, Bragg, Fran J., Bragg, Fran J., Chan, Wing-Le, Chandler, Mark A., Chandler, Mark A., Contoux, Camille, Contoux, Camille, Dolan, Aisling M., Dolan, Aisling M., Dowsett, Harry J., Dowsett, Harry J., Haywood, Alan M., Haywood, Alan M., Hill, Daniel J., Hill, Daniel J., Jost, Anne, Jost, Anne, Kamae, Youichi, Lohmann, Gerrit, Lohmann, Gerrit, Lunt, Daniel J., Lunt, Daniel J., Otto-Bliesner, Bette L., Otto-Bliesner, Bette L., Pickering, Steven J., Pickering, Steven J., Ramstein, Gilles, Ramstein, Gilles, Rosenbloom, Nan A., Rosenbloom, Nan A., Salzmann, Ulrich, Salzmann, Ulrich, Sohl, Linda, Sohl, Linda, Stepanek, Christian, Stepanek, Christian, Ueda, Hiroaki, Yan, Qing, Yan, Qing, Zhang, Zhongshi, Zhang, Zhongshi, 植田, 宏昭, 釜江, 陽一, 阿部, 彩子, 陳, 永利   +45 more
core   +6 more sources

Sea ice model evolution

, 2009
NERSC Technical Report no. 313.
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The sensitivity of the Greenland Ice Sheet to glacial-interglacial oceanic forcing [PDF]

, 2018
Observations suggest that during the last decades the Greenland Ice Sheet (GrIS) has experienced a gradually accelerating mass loss, in part due to the observed speed-up of several of Greenland's marine-terminating glaciers.
Blasco, Javier, Montoya Redondo, María Luisa, Robinson, Alexander James, Tabone, Ilaria, Álvarez Solas, Jorge   +4 more
core   +2 more sources