Results 101 to 110 of about 3,539,778 (300)
Modelling sea-level observations to investigate the source and magnitude of major meltwater pulses during termination 1 [PDF]
, 2006 The research presented in this thesis utilises available near and far-field sea- level records to provide constraints on the major rapid sea-level rise events that occurred during the most recent period of deglaciation (Termination 1).The far-field ...
Bassett, Sophie Elizabeth
core
, 2020 Accurate sea-ice prediction is essential for safe operations in the Arctic and potentially also for weather forecast at high-latitudes. The increasing number of sea-ice related satellite observations in the Arctic can be used to improve the model ...
Fritzner, Sindre Markus
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2008 Here we present a set of regional climate scenarios of sea level rise for the northeast Atlantic Ocean. In this study, the latest observations and results obtained with state-of-the-art climate models are combined.
Geert Jan van Oldenborgh +9 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oceanographic conditions beneath Fimbul Ice Shelf, Antarctica [PDF]
, 2012 Antarctic ice shelves play a key role in the global climate system, acting as important sites for the cooling of shelf waters, thereby facilitating deep and bottom water formation.
Abrahamsen, Einar Povl
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Numerical study of sea ice dynamics and wave-ice interactions in the marginal ice zone
, 2021 The Marginal Ice Zone (MIZ) is a highly dynamic region between the open ocean and the inner ice pack. The ice over this region is subjected to waves, introducing new forces but also changing the ice from a cohesive material to a mobile collection of ...
Auclair, Jean-Pierre
core
Estimation of Arctic Sea Ice Thickness Using HY-2B Altimeter Data
Remote SensingSea ice thickness is an important component of the Arctic environment, bearing crucial significance in investigations pertaining to global climate and environmental changes.
Chunyu Pang +4 more
doaj +1 more source