Results 101 to 110 of about 3,687,988 (259)

East Antarctic sea ice: observations and modelling

, 1998
The importance of monitoring sea ice for studies of global climate has been well noted for several decades. Observations have shown that sea ice exhibits large seasonal variability in extent, concentration and ...
Xingren Wu, Anthony P. Worby
core   +1 more source

A rapid transition from ice covered CO2–rich waters to a biologically mediated CO2 sink in the eastern Weddell Gyre [PDF]

, 2007
Circumpolar Deep Water (CDW), locally called Warm Deep Water (WDW), enters the Weddell Gyre in the southeast, roughly at 25° E to 30° E. In December 2002 and January 2003 we studied the effect of entrainment of WDW on the fugacity of carbon dioxide (fCO2)
Hoppema, Mario, Baar, H. J. W., Bakker, D. C. E., Schröder, M., Baar, H. J. W. de, Schroeder, M., Hoppema, M., Schröder, Michael, Geibert, W., de Baar, H. J. W.   +9 more
core   +2 more sources

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Sea Ice Physics and Modelling

, 2017
International audienceTo forecast the evolution of the sea ice cover in a particular region over a certain period of time, an automated prediction system must have a sea ice model.
Flato, Gregory, Rampal, Pierre, Flato, G., Bouillon, Sylvain, Lemieux, Jean-François, Losch, Martin, Dupont, Frédéric, Rampal, P., Williams, T., Losch, M., Williams, Timothy, Tremblay, Louis-Bruno, Vancoppenolle, Martin, Martin Losch, Timothy Williams, Frédéric Dupont, Jean-François Lemieux, Gregory Flato, Louis-Bruno Tremblay, Pierre Rampal, Martin Vancoppenolle, Sylvain Bouillon   +21 more
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Trimlines, blockfields and the vertical extent of the last ice sheet in southern Ireland [PDF]

, 2015
The research reported here was supported by UK NERC grant NER/B/S/2001/0919Trimlines separating glacially abraded lower slopes from blockfield-covered summits on Irish mountains have traditionally been interpreted as representing the upper limit of the ...
Stone, John O., John O. Stone, Ballantyne, Colin, Colin K. Ballantyne   +3 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source