Results 91 to 100 of about 3,687,988 (259)
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Reconstructing ice dynamics in the central sector of the last British-Irish Ice Sheet [PDF]
, 2010 The central sector (NW England and Scottish borders) of the last British-Irish Ice Sheet exhibits a palimpsest glacial geological and geomorphological signature characteristic of multi-phase ice flow and ice-marginal fluctuations. Despite its influential
LIVINGSTONE, STEPHEN,JOHN +1 more
core
Estimation of Arctic Sea Ice Thickness Using HY-2B Altimeter Data
Remote SensingSea ice thickness is an important component of the Arctic environment, bearing crucial significance in investigations pertaining to global climate and environmental changes.
Chunyu Pang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Potential subglacial lake locations and meltwater drainage pathways beneath the Antarctic and Greenland ice sheets [PDF]
, 2013 We use the Shreve hydraulic potential equation as a simplified approach to investigate potential subglacial lake locations and meltwater drainage pathways beneath the Antarctic and Greenland ice sheets. We validate the method by demonstrating its ability
Clark, Chris +13 more
core +2 more sources
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
, 2021 : This data set comprises time series of the monthly sea-ice area (SIA) in the Northern Hemisphere (1 file) and in the Southern Hemisphere (1 file).
Kern, Stefan, Doerr, Jakob, Notz, Dirk
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source