Results 71 to 80 of about 554,659 (340)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Relationships between Arctic sea ice drift and strength modelled by NEMO-LIM3.6 [PDF]

open access: yesThe Cryosphere, 2017
Sea ice cover and thickness have substantially decreased in the Arctic Ocean since the beginning of the satellite era. As a result, sea ice strength has been reduced, allowing more deformation and fracturing and leading to increased sea ice drift ...
D. Docquier   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Comparing heterogeneity of sea-ice models with viscous-plastic and Maxwell elasto-brittle rheology

open access: yesAnnals of Glaciology
Classical sea-ice models in climate model resolution do not resolve the small-scale physics of sea ice. New methods to address this problem include modifications to established viscous-plastic (VP) rheology models, sub-gridscale parameterizations or new ...
Mirjam Bourgett   +2 more
doaj   +1 more source

Future Arctic sea-ice loss reduces severity of cold air outbreaks in midlatitudes [PDF]

open access: yes, 2016
This is the final version of the article. Available from American Geophysical Union (AGU) via the DOI in this record.The effects of Arctic sea-ice loss on cold air outbreaks (CAOs) in midlatitudes remains unclear.
Ayarzagüena, B, Screen, James A.
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Numerical Simulations of Sea Ice Conditions in the Baltic Sea for 2010–2016 Winters Using the 3D CEMBS Model

open access: yesPolish Maritime Research, 2018
Sea ice conditions in the Baltic Sea during six latest winters – 2010/2011 to 2015/2016 are analysed using coupled ice–ocean numerical model 3D CEMBS (3D Coupled Ecosystem Model of the Baltic Sea).
Janecki Maciej   +4 more
doaj   +1 more source

Impacts of marine instability across the East Antarctic Ice Sheet on Southern Ocean dynamics [PDF]

open access: yes, 2016
Recent observations and modelling studies have demonstrated the potential for rapid and substantial retreat of large sectors of the East Antarctic Ice Sheet (EAIS). This has major implications for ocean circulation and global sea level.
Fogwill, CJ, Phipps, SJ, Turney, CSM
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The sensitivity of sea-ice brine fraction to the freezing temperature and orientation

open access: yesAnnals of Glaciology
The changing conditions in which sea ice forms and exists are likely to affect the properties of sea ice itself, and potential climate feedbacks need to be identified and understood to improve future projections.
Kial Douglas Stewart   +3 more
doaj   +1 more source

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