Results 61 to 70 of about 3,687,988 (259)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Recent trends in melting conditions on the Antarctic Peninsula and their implications for ice-sheet mass balance and sea level [PDF]

, 2006
Long-term records from meteorological stations on the Antarctic Peninsula show strong rising trends in the annual duration of melting conditions. In each case, the trend is statistically significant and represents a major increase in the potential for ...
Dowdeswell, J.A., Bassford, R. P., Glazovsky, A.F., Glazovsky, A. F., Siegert, M. J,, Macheret, Y.Y., Macheret, Y. Y., J. A. Dowdeswell, David G. Vaughan, A. F. Glazovsky, Oerlemans, J., R. P. Bassford, Bassford, R.P., Y. Y. Macheret, M. J. Siegert, Siegert, M. J., Dowdeswell, J. A., Siegert, M.J., J. Oerlemans, Dowling, Carolyn, Vaughn, Bruce H., Olofsson, Johan,, Lyons, W. Berry, Gooseff, Michael N., Fountain, Andrew G., McKnight, Diane M., Diane M. McKnight, Carolyn Dowling, Andrew G. Fountain, Michael N. Gooseff, W. Berry Lyons, Bruce H. Vaughn, Vaughan, David G.   +32 more
core   +1 more source

[Dataset] Low Fe availability for photosynthesis of sea-ice algae: Ex situ incubation of the ice diatom Fragilariopsis cylindrus in low-Fe sea ice using an ice tank [PDF]

, 2021
Data for Yoshida et al. "Low Fe availability for photosynthesis of sea-ice algae: Ex situ incubation of the ice diatom Fragilariopsis cylindrus in low-Fe sea ice using an ice ...
Yoshida, K., Suzuki, K., McMinn, Andrew, Karsh, Kristen, Yoshida, Kazuhiro, Seger, Andreas, Heil, P., Corkill, M., Karsh, K., Heil, Petra, Corkill, Matthew, McMinn, A., Suzuki, Koji, Seger, A., Andreas Seger, Kazuhiro Yoshida, Kristen Karsh, Koji Suzuki, Matthew Corkill, Andrew McMinn, Petra Heil   +20 more
core   +1 more source

High-resolution regional sea-ice model based on the discrete element method with boundary conditions from a large-scale model for ice drift

Annals of Glaciology
Understanding sea-ice dynamics at the floe scale is crucial to comprehend polar climate systems. While continuum models are commonly used to simulate large-scale sea-ice dynamics, they have limitations in accurately representing sea-ice behaviour at ...
Andrei Tsarau, Wenjun Lu, Raed Lubbad, Sveinung Løset, Yuan Zhang   +4 more
doaj   +1 more source

ICESHEET 1.0: a program to produce paleo-ice sheet reconstructions with minimal assumptions [PDF]

Geoscientific Model Development, 2016
We describe a program that produces paleo-ice sheet reconstructions using an assumption of steady-state, perfectly plastic ice flow behaviour. It incorporates three input parameters: ice margin, basal shear stress and basal topography.
E. J. Gowan, P. Tregoning, A. Purcell, J. Lea, O. J. Fransner, R. Noormets, J. A. Dowdeswell   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Modelling sea-level observations to investigate the source and magnitude of major meltwater pulses during termination 1 [PDF]

, 2006
The research presented in this thesis utilises available near and far-field sea- level records to provide constraints on the major rapid sea-level rise events that occurred during the most recent period of deglaciation (Termination 1).The far-field ...
Bassett, Sophie Elizabeth
core  

Modelling Sea Ice for Climate Studies

, 1990
This article reviews the state of the art of sea-ice modelling for climatic purposes. The large variability of sea ice, its effects on atmosphere and ocean dynamics, and its sensitivity to small changes in climate variables make the inclusion of an ...
van Ypersele de Strihou, Jean-Pascal
core   +1 more source

What sea-ice biogeochemical modellers need from observers

Elementa: Science of the Anthropocene, 2016
Numerical models can be a powerful tool helping to understand the role biogeochemical processes play in local and global systems and how this role may be altered in a changing climate.
Nadja Steiner, Clara Deal, Delphine Lannuzel, Diane Lavoie, François Massonnet, Lisa A. Miller, Sebastien Moreau, Ekaterina Popova, Jacqueline Stefels, Letizia Tedesco   +9 more
doaj   +1 more source

Estimating Arctic Sea Ice Thickness with CryoSat-2 Altimetry Data Using the Least Squares Adjustment Method

Sensors, 2020
Satellite altimeters can be used to derive long-term and large-scale sea ice thickness changes. Sea ice thickness retrieval is based on measurements of freeboard, and the conversion of freeboard to thickness requires knowledge of the snow depth and snow,
Feng Xiao, Fei Li, Shengkai Zhang, Jiaxing Li, Tong Geng, Yue Xuan   +5 more
doaj   +1 more source