Results 91 to 100 of about 1,764,252 (328)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A suite of coupled ocean-sea ice simulations examining the effect of regime shift in sea-ice thickness distribution on ice–ocean interaction in the Arctic Ocean [PDF]

Geoscientific Model Development
A major shift in Arctic sea ice occurred in 2007, transitioning from thicker, deformed ice to thinner, more uniform ice with reduced surface roughness. This abrupt change likely altered the dynamic and thermodynamic interactions between sea ice and ocean,
H. Sumata, H. Sumata, M. A. Granskog, P. Duarte   +3 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Supplementary material to "Changes in the annual sea ice freeze-thaw cycle in the Arctic Ocean from 2001 to 2018"

, 2022
Na Li, Ruibo Lei, Mario Hoppmann, Donald K. Perovich, Hailun He   +4 more
openalex   +1 more source

Recent Change—Sea Ice [PDF]

, 2015
Sea ice conditions in the Baltic Sea have been systematically monitored for more than 100 years. All sea ice-related parameters display large interannual variability, but a change towards milder ice winters has been observed over the past 100 years: in particular, the annual maximum ice extent has decreased and the length of the ice season has become ...
Jari J. Haapala, Iina Ronkainen, Natalija Schmelzer, Marzenna Sztobryn   +3 more
openaire   +1 more source

Winter storms accelerate the demise of sea ice in the Atlantic sector of the Arctic Ocean

Scientific Reports, 2019
A large retreat of sea-ice in the ‘stormy’ Atlantic Sector of the Arctic Ocean has become evident through a series of record minima for the winter maximum sea-ice extent since 2015.
Robert M. Graham, P. Itkin, A. Meyer, A. Meyer, A. Sundfjord, G. Spreen, L. Smedsrud, L. Smedsrud, G. Liston, B. Cheng, L. Cohen, D. Divine, I. Fer, A. Fransson, S. Gerland, J. Haapala, S. Hudson, M. Johansson, Jennifer King, Ioanna Merkouriadi, Algot K. Peterson, Algot K. Peterson, C. Provost, A. Randelhoff, A. Rinke, A. Rösel, N. Sennéchael, V. Walden, P. Duarte, P. Assmy, H. Steen, M. Granskog   +31 more
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Data on Physical Properties of Sea Ice in the Northern Barents Sea and Adjacent Arctic Basin From the Nansen Legacy Project

Geoscience Data Journal
Recent decline of sea ice in the Barents Sea represents a clear manifestation of the ongoing Arctic warming. This study presents a compilation of data sets on sea ice physics acquired during 2018–2022 during Nansen Legacy—a Norwegian multidisciplinary ...
Dmitry V. Divine, Adam Steer, Mats A. Granskog, Sebastian Gerland, Øyvind Foss, Anca Cristea, Polona Itkin, Malin Johansson, Emily Down, Agneta Fransson   +9 more
doaj   +1 more source

Flexural and compressive strength of the landfast sea ice in the Prydz Bay, East Antarctic

, 2021
Qingkai Wang, Zhaoquan Li, Lü Peng, Zhijun Li   +3 more
openalex   +1 more source