Results 91 to 100 of about 902,814 (336)
Impact of assimilating sea ice concentration, sea ice thickness and snow depth in a coupled ocean–sea ice modelling system [PDF]
The Cryosphere, 2018 Abstract. The accuracy of the initial state is very important for the quality of a forecast, and data assimilation is crucial for obtaining the best-possible initial state. For many years, sea-ice concentration was the only parameter used for assimilation into numerical sea-ice models.
Sindre Fritzner +4 more
openaire +4 more sources
Molecular Oncology, EarlyView.mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo +8 more
wiley +1 more source
The Finnish Ice Service, its sea-ice monitoring of the Baltic Sea and operational concept
Frontiers in Marine ScienceThe Finnish Ice Service is part of the Finnish Meteorological Institute (FMI). Based on the mandate in the Finnish legislation, it provides information on the ice conditions in the Baltic Sea.
Patrick B. Eriksson +7 more
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Quantifying the influence of sea ice on ocean microseism using observations from the Bering Sea, Alaska [PDF]
, 2011 Microseism is potentially affected by all processes that alter ocean wave heights. Because strong sea ice prevents large ocean waves from forming, sea ice can therefore significantly affect microseism amplitudes.
McNamara, Daniel E., Tsai, Victor C.
core +1 more source
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
Does Marine Surface Tension Have Global Biogeography? Addition for the OCEANFILMS Package
Atmosphere, 2018 We apply principles of Gibbs phase plane chemistry across the entire ocean-atmosphere interface to investigate aerosol generation and geophysical transfer issues.
Scott Elliott +19 more
doaj +1 more source
Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Molecular Oncology, EarlyView.Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides +13 more
wiley +1 more source