Results 101 to 110 of about 902,814 (336)
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Geochemistry, Geophysics, Geosystems, 2020 To evaluate the present sea ice changes in a longer‐term perspective, the knowledge of sea ice variability on preindustrial and geological time scales is essential.
Henriette M. Kolling +5 more
doaj +1 more source
The Grounding of an Ice Shelf in the Central Arctic Ocean: A Modeling Experiment [PDF]
, 2003 A numerical ice sheet model was used in a first test towards evaluating the hypothesis that, during a period of large-scale glaciation, an ice shelf emanating from the Barents/Kara Seas grounded across parts of the Lomonosov Ridge to a depth of around ...
Jakobsson, Martin +2 more
core +1 more source
Variability of the Northern Annular Mode's signature in winter sea ice concentration [PDF]
, 2003 Historical winter sea ice concentration data are used to examine the relation between the Northern Annular Mode (NAM) and the sea ice concentration in the Nordic seas over the past 50 years.
Krahmann, Gerd, Visbeck, Martin
core +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
SEASONAL VARIABILITY OF CENTRAL ARCTIC OCEAN SEA-ICE COVER: NEW BIOMARKER (IP25 AND PIP25) DATA FROM SEDIMENT TRAPS DEPLOYED ON SOUTHERN LOMONOSOV RIDGE [PDF]
, 2012 During the Polarstern 1995 Expedition, a long-term mooring system with two cone-shaped multi-sampling traps was deployed at the dominantly ice-covered western slope of the southern Lomonosov Ridge (81°04.5'N, 138°54.0'E, 1712 m water depth). One trap was
Fahl, Kirsten, Stein, Rüdiger
core
Taking stock of arctic sea ice and climate [PDF]
, 2009 The relationship among the cause-and-effect of the Arctic atmosphere, sea ice, and ocean is discussed. The increased vulnerability of the Arctic system to anomalous atmospheric forcing can be argued from the perspective that recent ice loss is the result
Francis, Jennifer +3 more
core +2 more sources
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
A direct helicopter EM sea ice thickness inversion, assessed with synthetic and field data [PDF]
, 2007 Accuracy and precision of helicopter electromagneticHEM sounding are the essential parameters for HEM seaicethickness profiling. For sea-ice thickness research, thequality of HEM ice thickness estimates must be better than10 cm to detect potential ...
Haas, Christian +2 more
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