Results 61 to 70 of about 1,764,252 (328)
Remote Sensing, 2020 The detection, monitoring, and forecasting of sea-ice conditions, including their extremes, is very important for ship navigation and offshore activities, and for monitoring of sea-ice processes and trends.
Marko Mäkynen +24 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Elementa: Science of the Anthropocene, 2015 Sea ice plays an important role in high latitude biogeochemical cycles, ecosystems, and climate. A complete understanding of how sea ice biogeochemistry contributes to these processes must take into account the metabolic functions of the sea ice ...
Jeff S. Bowman
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Multi-year spatial distribution of Antarctic sea ice (1988 - 2017)
Terrestrial, Atmospheric and Oceanic Sciences, 2021 In this study, we used daily sea-ice concentration data from the National Snow and Ice Data Center from 1988 to 2017 to investigate the spatial distribution of Antarctic sea ice by calculating the annual mean sea-ice concentration and multi-year sea ice ...
Xingdong Wang, Shuhui Yang, Zhankai Wu
doaj +1 more source
Sustained ocean changes contributed to sudden Antarctic sea ice retreat in late 2016
Nature Communications, 2019 After nearly three decades of observed increasing trends of Antarctic sea ice extent, in September-October-November 2016, there was a dramatic decrease. Here we document factors that contributed to that decrease. An atmosphere-only model with a specified
G. Meehl +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source