Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Increasing fall-winter energy loss from the Arctic Ocean and its role in Arctic temperature amplification [PDF]
, 2013 Copyright © 2010 American Geophysical UnionArctic surface temperatures have risen faster than the global average in recent decades, in part due to positive feedbacks associated with the rapidly diminishing sea ice cover.
Screen, James A., Simmonds, Ian
core +1 more source
Journal of Advances in Modeling Earth Systems, 2022 AbstractTo assess the effect of ocean‐atmosphere coupling in the climate response to forced sea ice loss, the Polar Amplification Model Intercomparison Project protocol includes centennial coupled atmosphere‐ocean general circulation model simulations with imposed sea ice loss.
Alexandre Audette, Paul J. Kushner
openaire +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Statistical Modeling of Arctic Sea Ice Concentrations for Northern Sea Route Shipping
Applied Sciences, 2023 The safe and efficient navigation of ships traversing the Northern Sea Route demands accurate information regarding sea ice concentration. However, the sea ice concentration forecasts employed to support such navigation are often flawed.
Da Wu +4 more
doaj +1 more source
The Effect of Changing Sea Ice on the Vulnerability of Arctic Coasts [PDF]
, 2014 Shorefast sea ice prevents the interaction of the land and the ocean in the Arctic winter and influences this interaction in the summer by governing the fetch.
Anderson, R S +2 more
core +3 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
AI4SeaIce: Toward Solving Ambiguous SAR Textures in Convolutional Neural Networks for Automatic Sea Ice Concentration Charting [PDF]
, 2022 Andreas Stokholm +5 more
openalex +1 more source
Investigation of North Pacific sea ice anomalies in the context of atmospheric and oceanic variability [PDF]
, 2001 Thesis (M.S.) University of Alaska Fairbanks, 2001This study investigates the main mode of variability in North Pacific sea ice and examines the relationship between sea ice concentration and northern hemispheric climate variability for the period 1968 ...
Tivy, Adrienne
core
Arctic Ocean sea ice response to Northern Annular Mode-like wind forcing [PDF]
, 2003 The response of the Arctic Ocean sea ice system to Northern Annular Mode-like wind forcing has been investigated using an ocean/sea ice general circulation model coupled to an atmospheric boundary layer model.
Krahmann, Gerd, Visbeck, Martin
core +1 more source