Results 111 to 120 of about 336,668 (362)

Exponentially decaying modes and long-term prediction of sea ice concentration using Koopman Mode Decomposition [PDF]

arXiv, 2019
Sea ice cover in the Arctic and Antarctic is an important indicator of changes in the climate, with important environmental, economic and security consequences. The complexity of the spatio-temporal dynamics of sea ice makes it difficult to assess the temporal nature of the changes - e.g. linear or exponential - and their precise geographical loci.
arxiv  

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Towards Sea Ice Remote Sensing with Space Detected GPS Signals: Demonstration of Technical Feasibility and Initial Consistency Check Using Low Resolution Sea Ice Information

Remote Sensing, 2010
This paper presents two space detected Global Positioning System (GPS)signals reflected off sea ice and compares the returned power profiles with independent estimates of ice concentration provided by the Advanced Microwave Scanning Radiometer (AMSR-E ...
Scott Gleason
doaj   +1 more source

Improving passive microwave sea ice concentration algorithms for coastal areas: applications to the Baltic Sea

, 2010
Sea ice concentration can be retrieved from passive microwave data using the NASA Team algorithm or the Artist Sea Ice (ASI) algorithm, for example.
Kaleschke, L., Maass, N.
core   +1 more source

Holocene carbon-cycle dynamics based on CO2 trapped in ice at Taylor Dome, Antarctica [PDF]

, 1999
A high-resolution ice-core record of atmospheric CO2 concentration over the Holocene epoch shows that the global carbon cycle has not been in steady state during the past 11,000 years.
Blunier, T., Deck, B., Fischer, Hubertus, Indermühle, A., Joos, F., Mastroianni, D., Meyer, R., Smith, J., Stauffer, B., Stocker, T. F., Tschumi, J., Wahlen, M.   +11 more
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Will Arctic sea ice thickness initialization improve seasonal forecast skill? [PDF]

, 2014
Arctic sea ice thickness is thought to be an important predictor of Arctic sea ice extent. However, coupled seasonal forecast systems do not generally use sea ice thickness observations in their initialization and are therefore missing a potentially ...
Bitz, Blanchard-Wrigglesworth, Blanchard-Wrigglesworth, Blanchard-Wrigglesworth, Chevallier, Chevallier, Collins, Day, Doblas-Reyes, Dunstone, E. Hawkins, Eicken, Guemas, Guemas, Holland, J. J. Day, Johns, Jung, Kaleschke, Koenigk, Koenigk, Latif, Laxon, Lindsay, Massonnet, Mathiot, McLaren, Persson, Pohlmann, S. Tietsche, Schröder, Serreze, Shaffrey, Sigmond, Stephenson, Stroeve, Tietsche, Tietsche, Wang, Yang   +39 more
core   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Navigability of the Northern Sea Route for Arc7 ice-class vessels during winter and spring sea-ice conditions

Advances in Climate Change Research, 2022
Sea ice hinders the navigability of the Arctic, especially in winter and spring. However, three Arc7 ice-class Liquefied Natural Gas carrying vessels safely transited the Northern Sea Route (NSR) without icebreaker assistance in January 2021.
Shi-Yi CHEN, Stefan Kern, Xin-Qing LI, Feng-Ming HUI, Yu-Fang YE, Xiao Cheng   +5 more
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