Results 111 to 120 of about 288,973 (326)

A Long-Term and Reproducible Passive Microwave Sea Ice Concentration Data Record for Climate Studies and Monitoring [PDF]

, 2013
A long-term, consistent, and reproducible satellite-based passive microwave sea ice concentration climate data record (CDR) is available for climate studies, monitoring, and model validation with an initial operation capability (IOC).
Meier, W. N., Peng, G., Savoie, M. H., Scott, D. J.   +3 more
core   +3 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Ecosystem model intercomparison of under-ice and total primary production in the Arctic Ocean [PDF]

, 2016
Previous observational studies have found increasing primary production (PP) in response to declining sea ice cover in the Arctic Ocean. In this study, under-ice PP was assessed based on three coupled ice-ocean-ecosystem models participating in the Forum
Ji, Rubao, Jin, Meibing, Lee, Younjoo J., Pendleton, Daniel, Popova, Ekaterina E., Varpe, Øystein, Yool, Andrew, Zhang, Jinlun   +7 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Satellite-derived ice data sets no. 2: Arctic monthly average microwave brightness temperatures and sea ice concentrations, 1973-1976 [PDF]

A summary data set for four years (mid 70's) of Arctic sea ice conditions is available on magnetic tape. The data include monthly and yearly averaged Nimbus 5 electrically scanning microwave radiometer (ESMR) brightness temperatures, an ice concentration
Comiso, J. C., Parkinson, C. L., Zwally, H. J.   +2 more
core   +1 more source

Study of Antarctic Sea Ice Based on Shipborne Camera Images and Deep Learning Method

Remote Sensing
Sea ice parameters are crucial for polar ship design. During China’s 39th Antarctic Scientific Expedition, ice condition from the entire navigation process of the research vessel Xuelong 2 was recorded using shipborne cameras.
Xiaodong Chen, Shaoping Guo, Qiguang Chen, Xiaodong Chen, Shunying Ji   +4 more
doaj   +1 more source

Net primary productivity estimates and environmental variables in the Arctic Ocean: An assessment of coupled physical-biogeochemical models [PDF]

, 2016
The relative skill of 21 regional and global biogeochemical models was assessed in terms of how well the models reproduced observed net primary productivity (NPP) and environmental variables such as nitrate concentration (NO3), mixed layer depth (MLD ...
Aksnes, Anderson, Arakawa, Ardyna, Ardyna, Armstrong, Arrigo, Arrigo, Aumont, Aumont, Babin, Balch, Bernard, Bertino, Blackford, Blanke, Bleck, Bluhm, Bouillon, Brugel, Buitenhuis, Buitenhuis, Butenschön, Campbell, Carmack, Carr, Cavalieri, Charalampopoulou, Codispoti, Coello-Camba, Coello-Camba, Comiso, Cota, Cotrim da Cunha, Coupel, Deal, Dee, DRAKKAR Group, Dunne, Dunne, Dunne, Dutkiewicz, Eppley, Fernández-Méndez, Fichefet, Forsythe, Friedrichs, Friedrichs, Gaspar, Geider, Gent, Gill, Giorgetta, Granskog, Gregg, Griffies, Hansen, Harrison, Harrison, Harrison, Heinze, Hibler, Hibler, Hill, Hu, Hunke, Huot, Ilyina, Jackett, Ji, Jin, Jin, Jin, Jin, Johnson, Jolliff, Jungclaus, Kim, Kishi, Klausmeier, Kosobokova, Kwiatkowski, Large, Large, Laroche, Laufkötter, Le Fouest, Le Fouest, Le Fouest, Le Fouest, Le Quéré, Lee, Lee, Lee, Lengaigne, Leu, Li, Lindsay, Lomas, Lovejoy, Ludwig, Lévy, Madec, Madec, Madec, Manda, Manizza, Manizza, Manizza, Marshall, Matrai, McCuen, McGillicuddy, McLaughlin, Menemenlis, Meybeck, Michel, Michel, Moore, Moriasi, Mundy, Nash, Notz, Oki, Oschlies, Pacanowski, R. C., and S. G. H. Philander, Peng, Peralta-Ferriz, Popova, Popova, Popova, Ralston, Reigstad, Reigstad, Richardson, Romanou, Romanou, Roullet, Russell, Saba, Saba, Sakshaug, Salas Mélia, Sallon, Samuelsen, Schmidt, Schmidt, Schweiger, Schwinger, Seitzinger, Semtner, Six, Slagstad, Slagstad, Slagstad, Smith, Smith, Steele, Stock, Stock, Stow, Sunda, Séférian, Takahashi, Tamelander, Taylor, Tedesco, Tegen, Timmermann, Timmermans, Tjiputra, Torres-Valdés, Tremblay, Tremblay, Tremblay, Tremblay, Tréguer, Vancoppenolle, Vancoppenolle, Vancoppenolle, Vernet, Vernet, Vichi, Vichi, Voldoire, Wassmann, Wassmann, Wassmann, Watanabe, Willmott, Winton, Yool, Yool, Yun, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang   +201 more
core   +6 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Pan-Arctic sea ice concentration from SAR and passive microwave [PDF]

The Cryosphere
Arctic sea ice monitoring is a fundamental prerequisite for anticipating and mitigating the impacts of climate change. Satellite-based sea ice observations have been subject to intense attention over the last few decades, with passive microwave (PMW ...
T. Wulf, J. Buus-Hinkler, S. Singha, H. Shi, M. B. Kreiner   +4 more
doaj   +1 more source