Results 101 to 110 of about 403,562 (281)

Sea ice extent and the global climate system

Polar Research, 2003
Sea ice is a remarkable component of the global climate system. It can form over up to about 10 % of the global ocean area, and creates an insulating barrier between the relatively warm seawater and the cold atmosphere, allowing a temperature difference that may be tens of degrees over only a couple of meters.
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Satellite Observation of Sea Ice Concentration Based on Chinese HY-1C/D Data

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The increasingly significant global warming has severely affected the Arctic region. The melting speed of sea ice is accelerating, and its spatial coverage is gradually shrinking, causing a series of ecological problems that cannot be ignored. Therefore,
Li Xu, Yiming Chen, Deyong Sun, Shengqiang Wang, Lijian Shi, Muhammad Bilal, Yongjun Jia, Shuyan Lang, Bin Zou   +8 more
doaj   +1 more source

Arctic sea ice decline contributes to thinning lake ice trend in northern Alaska

Environmental Research Letters, 2016
Field measurements, satellite observations, and models document a thinning trend in seasonal Arctic lake ice growth, causing a shift from bedfast to floating ice conditions. September sea ice concentrations in the Arctic Ocean since 1991 correlate well (
Vladimir A Alexeev, Christopher D Arp, Benjamin M Jones, Lei Cai   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A Bayesian Model for 20th Century Antarctic Sea Ice Extent Reconstruction

Earth and Space Science
Antarctic sea ice, a key component in the complex Antarctic climate system, is an important driver and indicator of the global climate. In the relatively short satellite‐observed period from 1979 to 2022 the sea ice extent has continuously increased ...
T. J. Maierhofer, M. N. Raphael, R. L. Fogt, M. S. Handcock   +3 more
doaj   +1 more source

Enhancing sea ice knowledge through assimilation of sea ice thickness from ENVISAT and CS2SMOS [PDF]

The Cryosphere
Arctic sea ice extent has declined significantly over the past four decades, opening up the Arctic to shipping and resource extraction while also impacting wildlife and local communities.
N. Williams, Y. Wang, F. Counillon, F. Counillon   +3 more
doaj   +1 more source

Auf dünnem Eis? Eisdickenänderungen im Nordpolarmeer [PDF]

, 2006
While the summer sea ice extent has beendecreasing in the Artic by 8% per decade for the past 30 years,the ice extent has actually increased slightlyin the Antarctic. Ice thickness changes are less well known. In the central Arctic, sea ice thinned by 43%
Haas, Christian
core  

Will Arctic sea ice thickness initialization improve seasonal forecast skill? [PDF]

, 2014
Arctic sea ice thickness is thought to be an important predictor of Arctic sea ice extent. However, coupled seasonal forecast systems do not generally use sea ice thickness observations in their initialization and are therefore missing a potentially ...
Bitz, Blanchard-Wrigglesworth, Blanchard-Wrigglesworth, Blanchard-Wrigglesworth, Chevallier, Chevallier, Collins, Day, Doblas-Reyes, Dunstone, E. Hawkins, Eicken, Guemas, Guemas, Holland, J. J. Day, Johns, Jung, Kaleschke, Koenigk, Koenigk, Latif, Laxon, Lindsay, Massonnet, Mathiot, McLaren, Persson, Pohlmann, S. Tietsche, Schröder, Serreze, Shaffrey, Sigmond, Stephenson, Stroeve, Tietsche, Tietsche, Wang, Yang   +39 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source