Results 81 to 90 of about 4,079,930 (328)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The last glaciation of Shetland : local ice cap or invasive ice sheet? [PDF]
, 2014 Issue ISBN: 978-82-92-39488-5 This work is supported by the Carnegie Trust for the Universities of ScotlandThe question of whether the Shetland Islands were covered by an ice cap or by an ice sheet during the last glacial cycle (40–10 ka) remains ...
Hall, A. M.
core +2 more sources
Geophysical Research Letters, 2023 Sea‐ice extent is predicted to decrease in a warming climate. However, despite global warming over the past century, total Antarctic sea ice remained relatively stable from 1979 until 2015, before strongly melting.
Quentin Dalaiden +5 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
How does internal variability influence the ability of CMIP5 models to reproduce the recent trend in Southern Ocean sea ice extent? [PDF]
The Cryosphere, 2013 Observations over the last 30 yr have shown that the sea ice extent in the Southern Ocean has slightly increased since 1979. Mechanisms responsible for this positive trend have not been well established yet. In this study we tackle two related issues:
V. Zunz, H. Goosse, F. Massonnet
doaj +1 more source
Improving Predictions of Arctic Sea Ice Extent
Eos, 2015 Scientists in the Sea Ice Prediction Network share and discuss their user-oriented forecasts of seasonal sea ice in a changing Arctic.
Julienne Stroeve +5 more
openaire +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The Impact of Stratospheric Circulation Extremes on Minimum Arctic Sea Ice Extent
Journal of Climate, 2017 Given the rapidly changing Arctic climate, there is an urgent need for improved seasonal predictions of Arctic sea ice. Yet, Arctic sea ice prediction is inherently complex.
K. Smith, L. Polvani, L. Tremblay
semanticscholar +1 more source
A scatterometer record of sea ice extents and backscatter: 1992–2016 [PDF]
The Cryosphere, 2018 Abstract. This paper presents the first long-term climate data record of sea ice extents and backscatter derived from intercalibrated satellite scatterometer missions (ERS, QuikSCAT and ASCAT) extending from 1992 to the present date (Verhoef et al., 2018).
M. Belmonte Rivas +5 more
openaire +6 more sources