Results 61 to 70 of about 25,918 (254)

How does internal variability influence the ability of CMIP5 models to reproduce the recent trend in Southern Ocean sea ice extent? [PDF]

The Cryosphere, 2013
Observations over the last 30 yr have shown that the sea ice extent in the Southern Ocean has slightly increased since 1979. Mechanisms responsible for this positive trend have not been well established yet. In this study we tackle two related issues:
V. Zunz, H. Goosse, F. Massonnet
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A scatterometer record of sea ice extents and backscatter: 1992–2016 [PDF]

The Cryosphere, 2018
Abstract. This paper presents the first long-term climate data record of sea ice extents and backscatter derived from intercalibrated satellite scatterometer missions (ERS, QuikSCAT and ASCAT) extending from 1992 to the present date (Verhoef et al., 2018).
M. Belmonte Rivas, M. Belmonte Rivas, I. Otosaka, I. Otosaka, A. Stoffelen, A. Verhoef   +5 more
openaire   +6 more sources

Improving Met Office seasonal predictions of Arctic sea ice using assimilation of CryoSat-2 thickness [PDF]

The Cryosphere, 2018
Interest in seasonal predictions of Arctic sea ice has been increasing in recent years owing, primarily, to the sharp reduction in Arctic sea-ice cover observed over the last few decades, a decline that is projected to continue.
E. W. Blockley, K. A. Peterson
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Polar Sea Ice Monitoring Using HY-2B Satellite Scatterometer and Scanning Microwave Radiometer Measurements

Remote Sensing
The Ku band microwave scatterometer (SCA) and scanning microwave radiometer (SMR) onboard HaiYang-2B (HY-2B) can simultaneously supply active and passive microwave observations over the polar region.
Tao Zeng, Lijian Shi, Yingni Shi, Dunwang Lu, Qimao Wang   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A twenty-first century structural change in Antarctica’s sea ice system

Communications Earth & Environment
From 1979 to 2016, total Antarctic sea ice extent experienced a positive trend with record winter maxima in 2012 and 2014. Record summer minima followed within the period 2017-2024, raising the possibility that the Antarctic sea ice system might be ...
Marilyn N. Raphael, Thomas J. Maierhofer, Ryan L. Fogt, William R. Hobbs, Mark S. Handcock   +4 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source