Results 71 to 80 of about 25,918 (254)

Revisiting the potential of melt pond fraction as a predictor for the seasonal Arctic sea ice extent minimum

Environmental Research Letters, 2015
The rapid change in Arctic sea ice in recent decades has led to a rising demand for seasonal sea ice prediction. A recent modeling study that employed a prognostic melt pond model in a stand-alone sea ice model found that September Arctic sea ice extent ...
Jiping Liu, Mirong Song, Radley M Horton, Yongyun Hu   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Can subseasonal to seasonal (S2S) forecast systems predict exceptionally rapid decrease and slow growth of Antarctic sea ice during 2022–2023?

Journal of Glaciology
Antarctic sea-ice extent (SIE) in 2023 hit the record low for both seasonal minimum and maximum, largely due to an exceptionally rapid decrease in November–December 2022 (periods 1 and 2) and exceptionally slow recovery in April–July 2023 (periods 3 and ...
Jingxu Chen, Jiping Liu, Chao-Yuan Yang, Qinghua Yang   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Bayesian Model for 20th Century Antarctic Sea Ice Extent Reconstruction

Earth and Space Science
Antarctic sea ice, a key component in the complex Antarctic climate system, is an important driver and indicator of the global climate. In the relatively short satellite‐observed period from 1979 to 2022 the sea ice extent has continuously increased ...
T. J. Maierhofer, M. N. Raphael, R. L. Fogt, M. S. Handcock   +3 more
doaj   +1 more source

Satellite Observation of Sea Ice Concentration Based on Chinese HY-1C/D Data

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The increasingly significant global warming has severely affected the Arctic region. The melting speed of sea ice is accelerating, and its spatial coverage is gradually shrinking, causing a series of ecological problems that cannot be ignored. Therefore,
Li Xu, Yiming Chen, Deyong Sun, Shengqiang Wang, Lijian Shi, Muhammad Bilal, Yongjun Jia, Shuyan Lang, Bin Zou   +8 more
doaj   +1 more source

Enhancing sea ice knowledge through assimilation of sea ice thickness from ENVISAT and CS2SMOS [PDF]

The Cryosphere
Arctic sea ice extent has declined significantly over the past four decades, opening up the Arctic to shipping and resource extraction while also impacting wildlife and local communities.
N. Williams, Y. Wang, F. Counillon, F. Counillon   +3 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source