Results 91 to 100 of about 4,079,930 (328)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

An assessment of key model parametric uncertainties in projections of Greenland Ice Sheet behavior [PDF]

, 2012
Lack of knowledge about the values of ice sheet model input parameters introduces substantial uncertainty into projections of Greenland Ice Sheet contributions to future sea level rise.
Stone, Emma J., N. Kirchner, K. Keller, Keller, K., Greve, Ralf, Applegate, P. J., Greve, R., R. Greve, Keller, Klaus, Kirchner, N., Applegate, Patrick J.,, Applegate, Patrick J., Kirchner, Nina, Stone, EJ, Kirchner, Nina,, E. J. Stone, Stone, E. J., P. J. Applegate   +17 more
core   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Factors influencing the stable carbon isotopic composition of suspended and sinking organic matter in the coastal Antarctic sea ice environment [PDF]

, 2011
A high resolution time-series analysis of stable carbon isotopic signatures in particulate organic carbon (δ13CPOC) and associated biogeochemical parameters in sea ice and surface waters provides an insight into the factors affecting δ13CPOC in the ...
Carson, D. S., Ganeshram, R.S., R. S. Ganeshram, S. F. Henley, A. E. Fallick, Fallick, A.E., J. Dougans, A. Clarke, Ganeshram, R. S.; id_orcid, Annett, A.L., Annett, Amber, Weston, K., Henley, S.F., Annett, A. L., Ganeshram, R. S., Carson, D.S., D. S. Carson, K. Weston, Dougans, J., Fallick, A. E., A. L. Annett, Crosta, X., A. Tait, X. Crosta, Henley, S. F., Tait, A., Clarke, A.   +26 more
core   +2 more sources

Improving Met Office seasonal predictions of Arctic sea ice using assimilation of CryoSat-2 thickness [PDF]

The Cryosphere, 2018
Interest in seasonal predictions of Arctic sea ice has been increasing in recent years owing, primarily, to the sharp reduction in Arctic sea-ice cover observed over the last few decades, a decline that is projected to continue.
E. W. Blockley, K. A. Peterson
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Polar Sea Ice Monitoring Using HY-2B Satellite Scatterometer and Scanning Microwave Radiometer Measurements

Remote Sensing
The Ku band microwave scatterometer (SCA) and scanning microwave radiometer (SMR) onboard HaiYang-2B (HY-2B) can simultaneously supply active and passive microwave observations over the polar region.
Tao Zeng, Lijian Shi, Yingni Shi, Dunwang Lu, Qimao Wang   +4 more
doaj   +1 more source

Impacts of freshwater changes on Antarctic sea ice in an eddy-permitting sea-ice–ocean model [PDF]

The Cryosphere, 2017
In a warming climate, satellite data indicate that the sea ice extent around Antarctica has increased over the last decades. One of the suggested explanations is the stabilizing effect of increased mass loss of the Antarctic ice sheet.
V. Haid, V. Haid, D. Iovino, S. Masina, S. Masina   +4 more
doaj   +1 more source

Skillful spring forecasts of September Arctic sea ice extent using passive microwave sea ice observations

, 2017
In this study, we demonstrate skillful spring forecasts of detrended September Arctic sea ice extent using passive microwave observations of sea ice concentration (SIC) and melt onset (MO).
A. Petty, David Schröder, J. Stroeve, Thorsten Markus, James R. Miller, N. Kurtz, D. Feltham, D. Flocco   +7 more
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source