Results 91 to 100 of about 25,918 (254)

An Initial Assessment of Antarctic Sea Ice Extent in the CMIP5 Models

Journal of Climate, 2013
Abstract This paper examines the annual cycle and trends in Antarctic sea ice extent (SIE) for 18 models used in phase 5 of the Coupled Model Intercomparison Project (CMIP5) that were run with historical forcing for the 1850s to 2005. Many of the models have an annual SIE cycle that differs markedly from that observed over the last 30 ...
Turner, John, Bracegirdle, Thomas J., Phillips, Tony, Marshall, Gareth J., Hosking, J. Scott   +4 more
openaire   +2 more sources

Decline in plankton diversity and carbon flux with reduced sea ice extent along the Western Antarctic Peninsula. [PDF]

Nat Commun, 2021
Lin Y, Moreno C, Marchetti A, Ducklow H, Schofield O, Delage E, Meredith M, Li Z, Eveillard D, Chaffron S, Cassar N.   +10 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Ice type matters: impacts of landfast and drift ice on body condition in a high Arctic seabird community

Frontiers in Marine Science
Sea ice, a central component of polar ecosystems, is undergoing profound changes due to climate change. In particular, the Arctic is experiencing unprecedented warming at quicker rates than other regions.
Christophe Sauser, Pierre Blévin, Olivier Chastel, Geir Wing Gabrielsen, Sveinn Are Hanssen, Erlend Lorentzen, Børge Moe, Sebastien Moreau, Kjetil Sagerup, Sebastien Descamps   +9 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The relationship between Antarctic sea-ice extent change and the main modes of sea-ice variability in austral winter

Polar Research
Accompanying global warming, Antarctic sea-ice extent shows a somewhat increasing trend from 1979 to 2014, followed by an abrupt decrease after 2016. Our previous study examined the change of Antarctic sea-ice extent in austral summer, autumn and spring.
Lejiang Yu, Cuijuan Sui, Haixia Dai
doaj   +1 more source