Results 101 to 110 of about 4,079,930 (328)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Evaluation of Operation IceBridge quick-look snow depth estimates on sea ice [PDF]
, 2015 We evaluate Operation IceBridge (OIB) ‘quick-look’ (QL) snow depth on sea ice retrievals using in situ measurements taken over immobile first-year ice (FYI) and multi-year ice (MYI) during March of 2014. Good agreement was found over undeformed FYI (-4.5
Joshua King +17 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Reconstructing ice dynamics in the central sector of the last British-Irish Ice Sheet [PDF]
, 2010 The central sector (NW England and Scottish borders) of the last British-Irish Ice Sheet exhibits a palimpsest glacial geological and geomorphological signature characteristic of multi-phase ice flow and ice-marginal fluctuations. Despite its influential
LIVINGSTONE, STEPHEN,JOHN +1 more
core
Importance of seasonal and annual layers in controlling backscatter to radar altimeters across the percolation zone of an ice sheet [PDF]
, 2006 Radar altimeters are one of the main tools for measuring elevation changes across the Antarctic and Greenland ice sheets and larger ice caps. A ground-based radar was deployed in autumn 2004 and spring 2006 in the percolation zone of the Greenland Ice ...
Scott, JBT +17 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Journal of GlaciologyAntarctic sea-ice extent (SIE) in 2023 hit the record low for both seasonal minimum and maximum, largely due to an exceptionally rapid decrease in November–December 2022 (periods 1 and 2) and exceptionally slow recovery in April–July 2023 (periods 3 and ...
Jingxu Chen +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
The gravitationally consistent sea-level fingerprint of future terrestrial ice loss [PDF]
, 2013 We solve the sea-level equation to investigate the pattern of the gravitationally self-consistent sea-level variations (fingerprints) corresponding to modeled scenarios of future terrestrial ice melt.
R. T. W. L. Hurkmans +5 more
core +1 more source
Impacts of Climate Change on Arctic Sea Ice
, 2023 Satellite sensors record a downward trend in Arctic sea ice extent for all months (Figure 2; Fox-Kemper et al., 2021). This trend is particularly pronounced in the summer months (June to October) in which ice extent of the most recent five years (2018 ...
Aksenov, Y. +6 more
core +1 more source