Results 121 to 130 of about 951,074 (349)
Changes in Sea Level along the South China Sea Coast Based on the Homogenized Tide Gauge Data
Journal of Marine Science and EngineeringTo estimate the changes in the annual mean sea level (MSL) and extreme sea levels (ESLs), the largest collection of tide gauge records from 10 tidal stations along the northern coast of the South China Sea (SCS) were analyzed in this study. Here, all the
Yan Li +5 more
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Predicting marsh vulnerability to sea-level rise using Holocene relative sea-level data
Nature Communications, 2018 Quantifying the vulnerability of tidal marsh ecosystems to relative sea-level rise (RSLR) is essential if the threat is to be mitigated. Here, the authors analyze the response of Great Britain’s tidal marshes to RSLR during the Holocene and predict an ...
Benjamin P. Horton +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
ASSESSING THE RISKS OF A FUTURE RAPID LARGE SEA LEVEL RISE: A REVIEW [PDF]
Our aim is to make an appropriate characterization and interpretation of the risk problem of rapid large sea level rise that reflects the very large uncertainty in present day knowledge concerning this possibility, and that will be useful in informing ...
Clark L. Goble +2 more
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Evaluating the role of coastal habitats and sea-level rise in hurricane risk mitigation: An ecological economic assessment method and application to a business decision [PDF]
, 2015 Sheila M. W. Reddy +16 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
, 2019 As climate change is becoming a global issue, the impact of sea level rise is increasingly becoming a threat to humans, wildlife, infrastructure, and ecosystems. To evaluate the effects of sea level rise on barrier islands and coastal regions, we studied
Johnson, Cara +2 more
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A Preliminary Assessment of Tidal Flooding along the New Hampshire Coast: Past, Present and Future [PDF]
, 2001 This report presents the results of a preliminary study that examines several critical coastal issues for New Hampshire including sea level fluctuations (past, present and future), shoreline migrations, and tidal flooding. Included are: 1) an analysis of
Adams, Jamie R., Ward, Larry G.
core +1 more source