Results 81 to 90 of about 942,530 (302)

Treading Water: Tools to Help US Coastal Communities Plan for Sea Level Rise Impacts

Frontiers in Marine Science, 2019
As communities grapple with rising seas and more frequent flooding events, they need improved projections of future rising and flooding over multiple time horizons, to assist in a multitude of planning efforts.
Emily A. Smith, William Sweet, Molly Mitchell, Ricardo Domingues, Ricardo Domingues, Christopher P. Weaver, Molly Baringer, Gustavo Goni, John Haines, J. Derek Loftis, John Boon, David Malmquist   +11 more
doaj   +1 more source

Upper limit for sea level projections by 2100 [PDF]

, 2014
We construct the probability density function of global sea level at 2100, estimating that sea level rises larger than 180 cm are less than 5% probable.
Grinsted, A., Jevrejeva, S., Moore, J.C.
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Economy-Wide Estimates of the Implications of Climate Change: Sea Level Rise [PDF]

The economy-wide implications of sea level rise in 2050 are estimated using a static computable general equilibrium model. Overall, general equilibrium effects increase the costs of sea level rise, but not necessarily in every sector or region.
Francesco Bosello, Marco Lazzarin, Richard S.J. Tol, Roberto Roson   +3 more
core   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Coastal subsidence and relative sea level rise

Environmental Research Letters, 2014
Subsurface fluid-pressure declines caused by pumping of groundwater or hydrocarbons can lead to aquifer-system compaction and consequent land subsidence.
S E Ingebritsen, D L Galloway
doaj   +1 more source

Long-term and recent changes in sea level in the Falkland Islands [PDF]

, 2010
Mean sea level measurements made at Port Louis in the Falkland Islands in 1981-2, 1984 and 2009, together with values from the nearby permanent tide gauge at Port Stanley, have been compared to measurements made at Port Louis in 1842 by James Clark Ross.
Aarup, Aldiss, Altamimi, Archiving, Validation, and Interpretation of Satellite Oceanographic Data (AVISO), Bevis, Bindoff, Church, Clapperton, D. T. Pugh, Domingues, Douglas, Folland, Herschel, Holgate, Hughes, Hunter, Jones, Kent, Kistler, Leuliette, Mathers, Meredith, Meredith, Merrifield, P. L. Woodworth, Pavlis, Peltier, Peltier, Peltier, Peltier, Peltier, Pugh, Pugh, R. M. Bingley, Rahmstorf, Reynolds, Reynolds, Roberts, Ross, Ross, Ross, Rostami, Thompson, Webb, Woodworth, Woodworth, Woodworth, Woodworth, Wunsch, Wöppelmann, Wöppelmann   +50 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Author Correction: Exploring spatial feedbacks between adaptation policies and internal migration patterns due to sea-level rise

Nature Communications, 2023
Lena Reimann, Bryan Jones, Nora Bieker, Claudia Wolff, Jeroen C.J.H. Aerts, Athanasios T. Vafeidis   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source